NP_001269140.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,798 Da
NCBI Official Full Name
protein NDRG2 isoform c
NCBI Official Synonym Full Names
NDRG family member 2
NCBI Official Synonym Symbols
NCBI Protein Information
protein NDRG2; syld709613 protein; cytoplasmic protein Ndr1; NDR1-related protein NDR2; N-myc downstream regulator 2; N-myc downstream-regulated gene 2 protein
UniProt Protein Name
Protein NDRG2
UniProt Synonym Protein Names
N-myc downstream-regulated gene 2 protein; Protein Syld709613
UniProt Synonym Gene Names
UniProt Entry Name
NDRG2_HUMAN
NCBI Summary for NDRG2
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for NDRG2
NDRG2: a pro-apoptotic protein that may be involved in dendritic cell and neuron differentiation. May have anti-tumor activity. Generally not expressed in tumor cell lines. Unlike Ndr1, Ndr2 and Ndr3 appear not to be controlled by N-myc or c-myc. The loss of NDRG2 expression has been shown to be a prognostic indicator in gastric carcinomas. Five isoforms of the human protein are produced by alternative splicing. Isoforms 1 and 2 are present in brain neurons and up-regulated in Alzheimer disease
Protein type: Tumor suppressor; Apoptosis
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: nucleoplasm; Golgi apparatus; centrosome; growth cone; perinuclear region of cytoplasm; cytoplasm; microtubule organizing center; cytosol
Molecular Function: protein binding
Biological Process: substantia nigra development; Wnt receptor signaling pathway; negative regulation of smooth muscle cell proliferation; negative regulation of cytokine production; cell differentiation
Research Articles on NDRG2
Precautions
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Pathways associated with NDRG2 elisa kit
Diseases associated with NDRG2 elisa kit
Organs/Tissues associated with NDRG2 elisa kit
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