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NRG 1 elisa kit :: Human Neuregulin 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS726463
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells-(Competitive)  /  $455 +1 FREE 8GB USB
48-Strip-Wells-(Sandwich)  /  $455 +1 FREE 8GB USB
96-Strip-Wells-(Competitive)  /  $660 +1 FREE 8GB USB
96-Strip-Wells-(Sandwich)  /  $660 +1 FREE 8GB USB
5x96-Strip-Wells-(Competitive)  /  $2,925 +3 FREE 8GB USB
5x96-Strip-Wells-(Sandwich)  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells-(Competitive)  /  $5,490 +6 FREE 8GB USB
10x96-Strip-Wells-(Sandwich)  /  $5,490 +6 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Neuregulin 1 (NRG 1), ELISA Kit

 Also Known As   

Human Neuregulin 1 ELISA Kit

 Product Gene Name   

NRG 1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    142445
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 Species Reactivity    Human
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
 Assay Type    Competitive or Sandwich
 Detection Range    10 25ng/mL
 Sensitivity    0.1ng/mL
 Highest Standards    20ng/mL
 Concentration of Standards    Concentration of Standards
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of NRG 1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for NRG 1 purchase    MBS726463 is a ready-to-use microwell, strip plate Competitive or Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Neuregulin 1 (NRG 1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 10 25ng/mL in biological research samples containing NRG 1, with an estimated sensitivity of 0.1ng/mL. The ELISA analytical biochemical technique of the MBS726463 kit is based on NRG 1 antibody-NRG 1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NRG 1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NRG 1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for NRG 1 elisa kit    Neurobiology
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 Typical Testing Data/Standard Curve (for reference only) of NRG 1 elisa kit    NRG 1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS726463. Click to request current manual
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NCBI/Uniprot data below describe general gene information for NRG 1. It may not necessarily be applicable to this product.
 NCBI GI #    119583821
 NCBI GeneID    3084
 NCBI Accession #    EAW63417.1 [Other Products]
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 UniProt Secondary Accession #    O14667; P98202; Q02298; Q02299; Q07110; Q07111; A5YAK4; A5YAK5; A8K1L2; B7Z4Z3; E9PHH4 [Other Products]
 UniProt Related Accession #    Q02297 [Other Products]
 Molecular Weight    46,226 Da
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 NCBI Official Full Name    neuregulin 1, isoform CRA_k
 NCBI Official Synonym Full Names    neuregulin 1
 NCBI Official Symbol    NRG1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    pro-neuregulin-1, membrane-bound isoform; pro-NRG1; glial growth factor; neu differentiation factor; sensory and motor neuron derived factor; heregulin, alpha (45kD, ERBB2 p185-activator)
 UniProt Protein Name    Pro-neuregulin-1, membrane-bound isoform
 UniProt Synonym Protein Names   
Acetylcholine receptor-inducing activity; ARIA; Breast cancer cell differentiation factor p45; Glial growth factor; Heregulin; HRG; Neu differentiation factor; Sensory and motor neuron-derived factor
 UniProt Gene Name    NRG1 [Similar Products]
 UniProt Synonym Gene Names    GGF; HGL; HRGA; NDF; SMDF; Pro-NRG1; ARIA; HRG [Similar Products]
 UniProt Entry Name    NRG1_HUMAN
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 NCBI Summary for NRG 1    The protein encoded by this gene is a membrane glycoprotein that that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Jun 2014]
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 UniProt Comments for NRG 1    NRG1: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. The cytoplasmic domain interacts with the LIM domain region of LIMK1. Interacts with ERBB3 and ERBB4. Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stomach, pancreas, and spleen. Isoform 3 is the predominant form in mesenchymal cells and in non-neuronal organs, whereas isoform 6 is the major neuronal form. Isoform 8 is expressed in spinal cord and brain. Isoform 9 is the major form in skeletal muscle cells; in the nervous system it is expressed in spinal cord and brain. Also detected in adult heart, placenta, lung, liver, kidney, and pancreas. Isoform 10 is expressed in nervous system: spinal cord motor neurons, dorsal root ganglion neurons, and brain. Predominant isoform expressed in sensory and motor neurons. Not detected in adult heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not expressed in fetal lung, liver and kidney. Type IV isoforms are brain-specific. Belongs to the neuregulin family. 10 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell development/differentiation; Cytokine; Ligand, receptor tyrosine kinase

Chromosomal Location of Human Ortholog: 8p12

Cellular Component: extracellular space; membrane; integral to plasma membrane; axon; cytoplasm; apical plasma membrane; extracellular region; neuromuscular junction; nucleus

Molecular Function: ErbB-2 class receptor binding; transmembrane receptor protein tyrosine kinase activator activity; protein binding; growth factor activity; ErbB-3 class receptor binding; cytokine activity; transcription cofactor activity; protein tyrosine kinase activator activity; receptor tyrosine kinase binding; receptor binding

Biological Process: regulation of protein heterodimerization activity; positive regulation of cell adhesion; transmembrane receptor protein tyrosine kinase activation (dimerization); cellular protein complex disassembly; wound healing; nerve growth factor receptor signaling pathway; neural crest cell development; cell morphogenesis; ventricular cardiac muscle cell differentiation; locomotory behavior; positive regulation of striated muscle cell differentiation; cardiac muscle cell differentiation; synaptogenesis; mammary gland development; cell communication; positive regulation of cardiac muscle cell proliferation; epidermal growth factor receptor signaling pathway; nervous system development; cell migration; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; neurotransmitter receptor metabolic process; regulation of protein homodimerization activity; MAPKKK cascade; neuron fate commitment; positive regulation of cell growth; peripheral nervous system development; cell proliferation; positive regulation of protein kinase B signaling cascade; embryonic development; glial cell fate commitment; innate immune response; negative regulation of secretion; positive regulation of Ras protein signal transduction; negative regulation of transcription, DNA-dependent; negative regulation of protein catabolic process; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Schizophrenia 6
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 Research Articles on NRG 1    1. An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with NRG 1 elisa kitDiseases associated with NRG 1 elisa kit
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downregulation Of ERBB2:ERBB3 Signaling Pathway antibodies  Downregulation Of ERBB2:ERBB3 Signaling Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 Disease Name  Pubmed Publications
 Schizophrenia Antibodies  >382 publications with NRG 1 and Schizophrenia
 Nervous System Diseases Antibodies  >103 publications with NRG 1 and Nervous System Diseases
 Disease Models, Animal Antibodies  >78 publications with NRG 1 and Disease Models, Animal
 Breast Neoplasms Antibodies  >39 publications with NRG 1 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >36 publications with NRG 1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >27 publications with NRG 1 and Heart Diseases
 Carcinoma Antibodies  >24 publications with NRG 1 and Carcinoma
 Cognition Disorders Antibodies  >23 publications with NRG 1 and Cognition Disorders
 Nerve Degeneration Antibodies  >14 publications with NRG 1 and Nerve Degeneration
 Heart Failure Antibodies  >13 publications with NRG 1 and Heart Failure
Organs/Tissues associated with NRG 1 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >328 publications with NRG 1 and Brain
 Muscle Antibodies  >83 publications with NRG 1 and Muscle
 Blood Antibodies  >61 publications with NRG 1 and Blood
 Embryonic Tissue Antibodies  >50 publications with NRG 1 and Embryonic Tissue
 Ganglia Antibodies  >48 publications with NRG 1 and Ganglia
 Lung Antibodies  >22 publications with NRG 1 and Lung
 Vascular Antibodies  >19 publications with NRG 1 and Vascular
 Bone Antibodies  >16 publications with NRG 1 and Bone
 Skin Antibodies  >9 publications with NRG 1 and Skin
 Liver Antibodies  >8 publications with NRG 1 and Liver
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