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NRG-1 elisa kit :: Human Neuregulin 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS008086 NRG-1 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Neuregulin 1 (NRG-1), ELISA Kit

 Also Known As   

Human Neuregulin 1 ELISA Kit

 Product Gene Name   

NRG-1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 8; NC_000008.10 (31496820..32622558). Location: 8p12
 OMIM    142445
 3D Structure    ModBase 3D Structure for Q02297
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 Species Reactivity    Human
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances
 Assay Type    Sandwich
 Detection Range    0.5 ng/ml - 16 ng/ml
 Sensitivity    0.1ng/ml
 Intra-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of NRG-1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for NRG-1 purchase    MBS008086 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Neuregulin 1 (NRG-1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.5 ng/ml - 16 ng/ml in biological research samples containing NRG-1, with an estimated sensitivity of 0.1ng/ml. The ELISA analytical biochemical technique of the MBS008086 kit is based on NRG-1 antibody-NRG-1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NRG-1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NRG-1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for NRG-1 elisa kit

   Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of NRG1 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS008086. Click to request current manual
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NCBI/Uniprot data below describe general gene information for NRG-1. It may not necessarily be applicable to this product.
 NCBI GI #    223462375
 NCBI GeneID    3084
 NCBI Accession #    AAI50610.1 [Other Products]
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 UniProt Primary Accession #    Q02297 [Other Products]
 UniProt Secondary Accession #    O14667; P98202; Q02298; Q02299; Q07110; Q07111; A5YAK4; A5YAK5; A8K1L2; B7Z4Z3; E9PHH4 [Other Products]
 UniProt Related Accession #    Q02297 [Other Products]
 Molecular Weight    70,392 Da
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 NCBI Official Full Name    Neuregulin 1
 NCBI Official Synonym Full Names    neuregulin 1
 NCBI Official Symbol    NRG1 [Similar Products]
 NCBI Official Synonym Symbols   
GGF; HGL; HRG; NDF; ARIA; GGF2; HRG1; HRGA; SMDF; MST131
[Similar Products]
 NCBI Protein Information    pro-neuregulin-1, membrane-bound isoform; MSTP131; pro-NRG1; glial growth factor; neu differentiation factor; neuregulin 1 type IV beta 3; neuregulin 1 type IV beta 1a; sensory and motor neuron derived factor; heregulin, alpha (45kD, ERBB2 p185-activator)
 UniProt Protein Name    Pro-neuregulin-1, membrane-bound isoform
 UniProt Synonym Protein Names   
Acetylcholine receptor-inducing activity; ARIA; Breast cancer cell differentiation factor p45; Glial growth factor; Heregulin; HRG; Neu differentiation factor; Sensory and motor neuron-derived factor
 UniProt Gene Name    NRG1 [Similar Products]
 UniProt Synonym Gene Names    GGF; HGL; HRGA; NDF; SMDF; Pro-NRG1; ARIA; HRG [Similar Products]
 UniProt Entry Name    NRG1_HUMAN
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 NCBI Summary for NRG-1    The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD). [provided by RefSeq, May 2009]
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 UniProt Comments for NRG-1    NRG1: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. The cytoplasmic domain interacts with the LIM domain region of LIMK1. Interacts with ERBB3 and ERBB4. Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stomach, pancreas, and spleen. Isoform 3 is the predominant form in mesenchymal cells and in non-neuronal organs, whereas isoform 6 is the major neuronal form. Isoform 8 is expressed in spinal cord and brain. Isoform 9 is the major form in skeletal muscle cells; in the nervous system it is expressed in spinal cord and brain. Also detected in adult heart, placenta, lung, liver, kidney, and pancreas. Isoform 10 is expressed in nervous system: spinal cord motor neurons, dorsal root ganglion neurons, and brain. Predominant isoform expressed in sensory and motor neurons. Not detected in adult heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not expressed in fetal lung, liver and kidney. Type IV isoforms are brain-specific. Belongs to the neuregulin family. 10 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; Cytokine; Membrane protein, integral; Motility/polarity/chemotaxis; Ligand, receptor tyrosine kinase

Chromosomal Location of Human Ortholog: 8p12

Cellular Component: extracellular space; membrane; integral to plasma membrane; axon; apical plasma membrane; cytoplasm; extracellular region; neuromuscular junction; nucleus

Molecular Function: ErbB-2 class receptor binding; protein binding; transmembrane receptor protein tyrosine kinase activator activity; growth factor activity; ErbB-3 class receptor binding; transcription cofactor activity; cytokine activity; protein tyrosine kinase activator activity; receptor tyrosine kinase binding; receptor binding

Biological Process: regulation of protein heterodimerization activity; positive regulation of cell adhesion; transmembrane receptor protein tyrosine kinase activation (dimerization); wound healing; cellular protein complex disassembly; nerve growth factor receptor signaling pathway; neural crest cell development; ventricular cardiac muscle cell differentiation; cell morphogenesis; locomotory behavior; positive regulation of striated muscle cell differentiation; cardiac muscle cell differentiation; synaptogenesis; mammary gland development; cell communication; positive regulation of cardiac muscle cell proliferation; epidermal growth factor receptor signaling pathway; nervous system development; cell migration; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; neurotransmitter receptor metabolic process; regulation of protein homodimerization activity; neuron fate commitment; MAPKKK cascade; positive regulation of cell growth; peripheral nervous system development; positive regulation of protein kinase B signaling cascade; cell proliferation; embryonic development; glial cell fate commitment; innate immune response; negative regulation of secretion; positive regulation of Ras protein signal transduction; negative regulation of transcription, DNA-dependent; negative regulation of protein catabolic process; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Schizophrenia 6
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 Research Articles on NRG-1    1. the expression of HRG precursor and HRG-1alpha in MFOC-3.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with NRG-1 elisa kitDiseases associated with NRG-1 elisa kit
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downregulation Of ERBB2:ERBB3 Signaling Pathway antibodies  Downregulation Of ERBB2:ERBB3 Signaling Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 Disease Name  Pubmed Publications
 Schizophrenia Antibodies  >346 publications with NRG-1 and Schizophrenia
 Nervous System Diseases Antibodies  >95 publications with NRG-1 and Nervous System Diseases
 Neoplasms Antibodies  >75 publications with NRG-1 and Neoplasms
 Breast Neoplasms Antibodies  >33 publications with NRG-1 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >28 publications with NRG-1 and Cardiovascular Diseases
 Cognition Disorders Antibodies  >21 publications with NRG-1 and Cognition Disorders
 Carcinoma Antibodies  >20 publications with NRG-1 and Carcinoma
 Heart Diseases Antibodies  >20 publications with NRG-1 and Heart Diseases
 Nerve Degeneration Antibodies  >13 publications with NRG-1 and Nerve Degeneration
 Drug Toxicity Antibodies  >12 publications with NRG-1 and Drug Toxicity
Organs/Tissues associated with NRG-1 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >292 publications with NRG-1 and Nerve
 Brain Antibodies  >288 publications with NRG-1 and Brain
 Bone Antibodies  >14 publications with NRG-1 and Bone
 Eye Antibodies  >8 publications with NRG-1 and Eye
 Liver Antibodies  >7 publications with NRG-1 and Liver
 Skin Antibodies  >7 publications with NRG-1 and Skin
 Kidney Antibodies  >6 publications with NRG-1 and Kidney
 Intestine Antibodies  >5 publications with NRG-1 and Intestine
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