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NEFL elisa kit :: Human Neurofilament, Light Polypeptide (NEFL) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS450333 (SPECIAL PROMOTIONAL PRICING for a limited time)
Typical Standard Curve/Testing Data
Unit / Price
48-Strip-Wells  /  $370 +1 FREE 8GB USB
96-Strip-Wells  /  $495 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,200 +2 FREE 8GB USB
10x96-Strip-Wells  /  $4,265 +5 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Neurofilament, Light Polypeptide (NEFL), ELISA Kit

★Popular Item★
 Also Known As   

Human Neurofilament, Light Polypeptide (NEFL) ELISA Kit

 Product Synonym Names    CMT1F; CMT2E; NF-L; NF68; NFL; 68 kDa neurofilament protein; Neurofilament triplet L protein
 Product Gene Name   

NEFL elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    X05608 Genomic DNA
 3D Structure    ModBase 3D Structure for P07196
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 Species Reactivity    Human
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 Samples    Serum, plasma, cerebrospinal fluid and other biological fluids.
 Assay Type    Sandwich
 Detection Range    15.625-1000pg/mL
 Sensitivity    5.9pg/mL
 Intra Assay    CV<10%
 Inter Assay    CV<12%
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 Preparation and Storage    For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of NEFL elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for NEFL purchase    MBS450333 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Neurofilament, Light Polypeptide (NEFL) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 15.625-1000pg/mL in biological research samples containing NEFL, with an estimated sensitivity of 5.9pg/mL. The ELISA analytical biochemical technique of the MBS450333 kit is based on NEFL antibody-NEFL antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NEFL antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NEFL. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, cerebrospinal fluid and other biological fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Typical Standard Curve/Testing Data of NEFL elisa kit    NEFL elisa kit Typical Standard Curve/Testing Data image
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Sample Manual Insert of MBS450333. Click to request current manual
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NCBI/Uniprot data below describe general gene information for NEFL. It may not necessarily be applicable to this product.
 NCBI GI #    105990539
 NCBI GeneID    4747
 NCBI Accession #    NP_006149.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006158.4 [Other Products]
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 UniProt Primary Accession #    P07196 [Other Products]
 UniProt Secondary Accession #    Q16154; Q8IU72; B9ZVN2 [Other Products]
 UniProt Related Accession #    P07196 [Other Products]
 Molecular Weight    61,517 Da
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 NCBI Official Full Name    neurofilament light polypeptide
 NCBI Official Synonym Full Names    neurofilament light
 NCBI Official Symbol    NEFL [Similar Products]
 NCBI Official Synonym Symbols   
NFL; NF-L; NF68; CMT1F; CMT2E; PPP1R110
[Similar Products]
 NCBI Protein Information    neurofilament light polypeptide
 UniProt Protein Name    Neurofilament light polypeptide
 UniProt Synonym Protein Names   
68 kDa neurofilament protein; Neurofilament triplet L protein
 Protein Family    Neurofilament light polypeptide
 UniProt Gene Name    NEFL [Similar Products]
 UniProt Synonym Gene Names    NF68; NFL; NF-L [Similar Products]
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 NCBI Summary for NEFL    Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008]
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 UniProt Comments for NEFL    Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.
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 Research Articles on NEFL    1. We conclude that the NEFL N98S mutation is associated with a dominant intermediate Charcot-Marie-Tooth disease phenotype characterized by early-onset sensorimotor neuropathy delaying motor milestones, which may evolve into a severe and complex clinical picture including cerebellar ataxia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with NEFL elisa kitDiseases associated with NEFL elisa kit
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Association Between Physico-Chemical Features And Toxicity Associated Pathways antibodies  Association Between Physico-Chemical Features And Toxicity Associated Pathways Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CREB Phosphorylation Through The Activation Of CaMKII Pathway antibodies  CREB Phosphorylation Through The Activation Of CaMKII Pathway Diagram
 CREB Phosphorylation Through The Activation Of Ras Pathway antibodies  CREB Phosphorylation Through The Activation Of Ras Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >73 publications with NEFL and Nervous System Diseases
 Peripheral Nervous System Diseases Antibodies  >58 publications with NEFL and Peripheral Nervous System Diseases
 Brain Diseases Antibodies  >12 publications with NEFL and Brain Diseases
 Atrophy Antibodies  >12 publications with NEFL and Atrophy
 Breast Neoplasms Antibodies  >9 publications with NEFL and Breast Neoplasms
 Disease Models, Animal Antibodies  >6 publications with NEFL and Disease Models, Animal
 Charcot-Marie-Tooth disease, Type 2E Antibodies  >4 publications with NEFL and Charcot-Marie-Tooth disease, Type 2E
 Ataxia Antibodies  >3 publications with NEFL and Ataxia
 Lung Neoplasms Antibodies  >3 publications with NEFL and Lung Neoplasms
 Hypertension Antibodies  >2 publications with NEFL and Hypertension
Organs/Tissues associated with NEFL elisa kit
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >45 publications with NEFL and Nerve
 Brain Antibodies  >33 publications with NEFL and Brain
 Prostate Antibodies  >11 publications with NEFL and Prostate
 Spinal Cord Antibodies  >9 publications with NEFL and Spinal Cord
 Lung Antibodies  >6 publications with NEFL and Lung
 Eye Antibodies  >4 publications with NEFL and Eye
 Bone Marrow Antibodies  >3 publications with NEFL and Bone Marrow
 Ganglia Antibodies  >2 publications with NEFL and Ganglia
 Embryonic Tissue Antibodies  >2 publications with NEFL and Embryonic Tissue
 Kidney Antibodies  >2 publications with NEFL and Kidney
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