NP_000426.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
243,631 Da
NCBI Official Full Name
neurogenic locus notch homolog protein 3
NCBI Official Synonym Full Names
notch 3
NCBI Official Synonym Symbols
IMF2; LMNS; CASIL; CADASIL; CADASIL1 [Similar Products]
NCBI Protein Information
neurogenic locus notch homolog protein 3
UniProt Protein Name
Neurogenic locus notch homolog protein 3
UniProt Synonym Gene Names
NCBI Summary for NOTCH3
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]
UniProt Comments for NOTCH3
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination (PubMed:15350543). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs ().
Research Articles on NOTCH3
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Products associated with NOTCH3 elisa kit
Pathways associated with NOTCH3 elisa kit
Diseases associated with NOTCH3 elisa kit
Organs/Tissues associated with NOTCH3 elisa kit
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