NP_001092926.2
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
18,048 Da
NCBI Official Full Name
neuropeptide W preproprotein
NCBI Official Synonym Full Names
neuropeptide W
NCBI Protein Information
neuropeptide W; hPPL8; preproprotein L8; prepro-neuropeptide W
UniProt Protein Name
Neuropeptide W
UniProt Synonym Protein Names
Preproprotein L8; hPPL8
UniProt Synonym Gene Names
UniProt Entry Name
NPW_HUMAN
NCBI Summary for NPW
The product of this gene is processed into 23- and 30-amino acid neuropeptides that bind and activate two G-protein coupled receptors in the central nervous system. The neuropeptides have been shown to enhance cortisol secretion from adrenal cells through the adenylate cyclase/protein kinase A signaling cascade. The preproprotein is translated using a non-AUG initiation codon that is inferred from analyses of the mouse ortholog. [provided by RefSeq, Jul 2008]
UniProt Comments for NPW
NPW: Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress. NPW23 activates GPR7 and GPR8 more efficiently than NPW30. Belongs to the neuropeptide B/W family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: extracellular region
Molecular Function: protein binding; G-protein-coupled receptor binding
Biological Process: G-protein coupled receptor protein signaling pathway; neuropeptide signaling pathway; feeding behavior
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Products associated with NPW elisa kit
Pathways associated with NPW elisa kit
Diseases associated with NPW elisa kit
Organs/Tissues associated with NPW elisa kit
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