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NBN elisa kit :: Human Nibrin, NBN ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2602736
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $260 +1 FREE 8GB USB
96-Strip-Wells  /  $405 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,615 +2 FREE 8GB USB
10x96-Strip-Wells  /  $2,880 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Nibrin, NBN, ELISA Kit

★Popular Item★
 Also Known As   

Human Nibrin, NBN ELISA Kit

 Product Gene Name   

NBN elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    gene 609135
 3D Structure    ModBase 3D Structure for O60934
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 Species Reactivity    Human
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 Specificity    No cross-reaction with other factors.
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 Samples    Human serum, plasma or Cell Culture Supernatant and organizations in the natural and recombinant NBN concentration
 Assay Type    Sandwich
 Detection Range    20 ng/ml-0.312 ng/ml
 Sensitivity    0.06 ng/ml.
 Intra-assay Precision    <= 8%
 Inter-assay Precision    <= 12%
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of NBN elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for NBN purchase    MBS2602736 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Nibrin, NBN, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 20 ng/ml-0.312 ng/ml in biological research samples containing NBN, with an estimated sensitivity of 0.06 ng/ml. The ELISA analytical biochemical technique of the MBS2602736 kit is based on NBN antibody-NBN antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NBN antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NBN. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Human serum, plasma or Cell Culture Supernatant and organizations in the natural and recombinant NBN concentration. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for NBN elisa kit

   Priciple of the assay: This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is human NBN monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.
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 Typical Testing Data/Standard Curve (for reference only) of NBN elisa kit    NBN elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2602736. Click to request current manual
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NCBI/Uniprot data below describe general gene information for NBN. It may not necessarily be applicable to this product.
 NCBI GI #    33356172
 NCBI GeneID    4683
 NCBI Accession #    NP_002476.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002485.4 [Other Products]
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 UniProt Primary Accession #    O60934 [Other Products]
 UniProt Secondary Accession #    O60672; Q32NF7; Q53FM6; Q63HR6; Q7LDM2; B2R626; B2RNC5 [Other Products]
 UniProt Related Accession #    O60934 [Other Products]
 Molecular Weight    84,959 Da
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 NCBI Official Full Name    nibrin
 NCBI Official Synonym Full Names    nibrin
 NCBI Official Symbol    NBN [Similar Products]
 NCBI Official Synonym Symbols   
ATV; NBS; P95; NBS1; AT-V1; AT-V2
[Similar Products]
 NCBI Protein Information    nibrin; cell cycle regulatory protein p95; Nijmegen breakage syndrome 1 (nibrin); p95 protein of the MRE11/RAD50 complex
 UniProt Protein Name    Nibrin
 UniProt Synonym Protein Names   
Cell cycle regulatory protein p95; Nijmegen breakage syndrome protein 1
 Protein Family    Nibrin
 UniProt Gene Name    NBN [Similar Products]
 UniProt Synonym Gene Names    NBS; NBS1; P95 [Similar Products]
 UniProt Entry Name    NBN_HUMAN
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 NCBI Summary for NBN    Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for NBN    NBS1: a member of the MRE11/RAD50 double-strand break repair complex. Involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. Mutation results in the Nijmegen breakage syndrome (NBS), an autosomal recessive chromosomal instability syndrome.

Protein type: DNA repair, damage; Cell cycle regulation

Chromosomal Location of Human Ortholog: 8q21

Cellular Component: nucleoplasm; PML body; Mre11 complex; nuclear chromosome, telomeric region; nucleolus; replication fork; nucleus; nuclear inclusion body

Molecular Function: ATP-dependent DNA helicase activity; protein binding; damaged DNA binding; protein N-terminus binding; transcription factor binding

Biological Process: DNA damage response, signal transduction by p53 class mediator; mitotic cell cycle checkpoint; positive regulation of kinase activity; isotype switching; DNA repair; positive regulation of protein amino acid autophosphorylation; double-strand break repair via homologous recombination; DNA duplex unwinding; regulation of DNA replication initiation; cell proliferation; meiotic cell cycle; mitotic cell cycle G2/M transition DNA damage checkpoint; double-strand break repair; DNA damage checkpoint; blastocyst growth; neuromuscular process controlling balance; cell cycle arrest; telomere maintenance

Disease: Leukemia, Acute Lymphoblastic; Nijmegen Breakage Syndrome; Aplastic Anemia
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 Research Articles on NBN    1. The adjusted HR relating smoking to mortality in non-small cell lung cancer (NSCLC) was greater for cases with the GG genotype of NBS1 rs1061302 than for cases with AA/AG genotypes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NBN elisa kitPathways associated with NBN elisa kit
 Reference Product  PubMed Publications
 RAD50 elisa kit  >241 publications with NBN and RAD50
 MRE11A elisa kit  >185 publications with NBN and MRE11A
 ATM elisa kit  >181 publications with NBN and ATM
 BRCA1 elisa kit  >69 publications with NBN and BRCA1
 ATR elisa kit  >51 publications with NBN and ATR
 H2AFX elisa kit  >38 publications with NBN and H2AFX
 MDC1 elisa kit  >28 publications with NBN and MDC1
 PRKDC elisa kit  >15 publications with NBN and PRKDC
 CHEK2 elisa kit  >13 publications with NBN and CHEK2
 FANCD2 elisa kit  >12 publications with NBN and FANCD2
 Products by Pathway  Pathway Diagram
 ATM Mediated Phosphorylation Of Repair Proteins Pathway antibodies  ATM Mediated Phosphorylation Of Repair Proteins Pathway Diagram
 ATM Mediated Response To DNA Double-strand Break Pathway antibodies  ATM Mediated Response To DNA Double-strand Break Pathway Diagram
 Assembly Of The RAD50-MRE11-NBS1 Complex At DNA Double-strand Breaks Pathway antibodies  Assembly Of The RAD50-MRE11-NBS1 Complex At DNA Double-strand Breaks Pathway Diagram
 BARD1 Signaling Events Pathway antibodies  BARD1 Signaling Events Pathway Diagram
 BRCA1-associated Genome Surveillance Complex (BASC) Pathway antibodies  BRCA1-associated Genome Surveillance Complex (BASC) Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 DNA Damage Response Pathway antibodies  DNA Damage Response Pathway Diagram
 Double-Strand Break Repair Pathway antibodies  Double-Strand Break Repair Pathway Diagram
 Homologous Recombination Repair Pathway antibodies  Homologous Recombination Repair Pathway Diagram
 Homologous Recombination Pathway antibodies  Homologous Recombination Pathway Diagram
Diseases associated with NBN elisa kitOrgans/Tissues associated with NBN elisa kit
 Disease Name  Pubmed Publications
 Nijmegen Breakage Syndrome Antibodies  >214 publications with NBN and Nijmegen Breakage Syndrome
 Ataxia Antibodies  >189 publications with NBN and Ataxia
 Neoplasms Antibodies  >185 publications with NBN and Neoplasms
 Nervous System Diseases Antibodies  >80 publications with NBN and Nervous System Diseases
 Breast Neoplasms Antibodies  >57 publications with NBN and Breast Neoplasms
 Skin Diseases Antibodies  >56 publications with NBN and Skin Diseases
 Lymphoma Antibodies  >32 publications with NBN and Lymphoma
 Carcinoma Antibodies  >32 publications with NBN and Carcinoma
 Leukemia Antibodies  >31 publications with NBN and Leukemia
 Anemia Antibodies  >19 publications with NBN and Anemia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >50 publications with NBN and Blood
 Brain Antibodies  >21 publications with NBN and Brain
 Lung Antibodies  >19 publications with NBN and Lung
 Liver Antibodies  >12 publications with NBN and Liver
 Skin Antibodies  >11 publications with NBN and Skin
 Bladder Antibodies  >9 publications with NBN and Bladder
 Bone Antibodies  >9 publications with NBN and Bone
 Prostate Antibodies  >8 publications with NBN and Prostate
 Kidney Antibodies  >7 publications with NBN and Kidney
 Bone Marrow Antibodies  >5 publications with NBN and Bone Marrow
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