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N AChR elisa kit :: Human Nicotinic acetylcholine receptor ELISA Kit

Scan QR to view Datasheet Catalog #    MBS722705
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $455 +1 FREE 8GB USB
96-Strip-Wells  /  $660 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Nicotinic acetylcholine receptor (N AChR), ELISA Kit

 Also Known As   

Human Nicotinic acetylcholine receptor ELISA Kit

 Product Gene Name   

N AChR elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    gene 600513
 3D Structure    ModBase 3D Structure for P43681
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 Species Reactivity    Human
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
 Assay Type    Competitive
 Detection Range    0.5-10ng/mL
 Sensitivity    0.1ng/mL
 Highest Standards    10ng/mL
 Concentration of Standards    Concentration of Standards
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of N AChR elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for N AChR purchase    MBS722705 is a ready-to-use microwell, strip plate Competitive ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Nicotinic acetylcholine receptor (N AChR) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.5-10ng/mL in biological research samples containing N AChR, with an estimated sensitivity of 0.1ng/mL. The ELISA analytical biochemical technique of the MBS722705 kit is based on N AChR antibody-N AChR antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect N AChR antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, N AChR. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for N AChR elisa kit    Neurobiology
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 Typical Testing Data/Standard Curve (for reference only) of N AChR elisa kit    N AChR elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS722705. Click to request current manual
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NCBI/Uniprot data below describe general gene information for N AChR. It may not necessarily be applicable to this product.
 NCBI GI #    854159
 NCBI GeneID    1137
 NCBI Accession #    CAA60959.1 [Other Products]
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 UniProt Primary Accession #    P43681 [Other Products]
 UniProt Secondary Accession #    Q4JGR7; Q4VAQ5; Q4VAQ6 [Other Products]
 UniProt Related Accession #    P43681 [Other Products]
 Molecular Weight    60,994 Da
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 NCBI Official Full Name    nicotinic acetylcholine receptor, partial
 NCBI Official Synonym Full Names    cholinergic receptor, nicotinic, alpha 4 (neuronal)
 NCBI Official Symbol    CHRNA4 [Similar Products]
 NCBI Official Synonym Symbols   
EBN; BFNC; EBN1; NACHR; NACRA4; NACHRA4
[Similar Products]
 NCBI Protein Information    neuronal acetylcholine receptor subunit alpha-4; cholinergic receptor, nicotinic, alpha polypeptide 4; neuronal nicotinic acetylcholine receptor alpha-4 subunit
 UniProt Protein Name    Neuronal acetylcholine receptor subunit alpha-4
 Protein Family    Nicotinic acetylcholine receptor-binding protein
 UniProt Gene Name    CHRNA4 [Similar Products]
 UniProt Synonym Gene Names    NACRA4 [Similar Products]
 UniProt Entry Name    ACHA4_HUMAN
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 NCBI Summary for N AChR    This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
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 UniProt Comments for N AChR    nAChRA4: a ligand-gated ion channels that binds acetylcholine and mediates fast signal transmission at synapses. After binding acetylcholine, these pentameric receptors undergo an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. An integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor.

Protein type: Membrane protein, multi-pass; Channel, ligand-gated; Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 20q13.33

Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; postsynaptic membrane; cell soma; membrane; dendrite; integral to membrane; plasma membrane; cell junction; external side of plasma membrane

Molecular Function: acetylcholine receptor activity; acetylcholine binding; nicotinic acetylcholine-activated cation-selective channel activity; ligand-gated ion channel activity

Biological Process: response to nicotine; regulation of action potential; B cell activation; behavioral response to nicotine; locomotory behavior; respiratory gaseous exchange; DNA repair; sensory perception of pain; signal transduction; regulation of dopamine secretion; synaptic transmission, cholinergic; neurological system process; synaptic transmission; membrane depolarization; regulation of inhibitory postsynaptic membrane potential; regulation of membrane potential; calcium ion transport; response to hypoxia; ion transport; response to oxidative stress; cognition

Disease: Epilepsy, Nocturnal Frontal Lobe, 1; Tobacco Addiction, Susceptibility To
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 Research Articles on N AChR    1. A significant association between CHRNA4 variants and a subgroup of smokers.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with N AChR elisa kitPathways associated with N AChR elisa kit
 Reference Product  PubMed Publications
 CHRNB2 elisa kit  >61 publications with N AChR and CHRNB2
 CHRNA2 elisa kit  >22 publications with N AChR and CHRNA2
 CHRNA3 elisa kit  >15 publications with N AChR and CHRNA3
 CHRNA7 elisa kit  >15 publications with N AChR and CHRNA7
 CHRNB4 elisa kit  >12 publications with N AChR and CHRNB4
 NGF elisa kit  >2 publications with N AChR and NGF
 Products by Pathway  Pathway Diagram
 Acetylcholine Binding And Downstream Events Pathway antibodies  Acetylcholine Binding And Downstream Events Pathway Diagram
 Activation Of Nicotinic Acetylcholine Receptors Pathway antibodies  Activation Of Nicotinic Acetylcholine Receptors Pathway Diagram
 Cholinergic Synapse Pathway antibodies  Cholinergic Synapse Pathway Diagram
 Highly Calcium Permeable Nicotinic Acetylcholine Receptors Pathway antibodies  Highly Calcium Permeable Nicotinic Acetylcholine Receptors Pathway Diagram
 Highly Calcium Permeable Postsynaptic Nicotinic Acetylcholine Receptors Pathway antibodies  Highly Calcium Permeable Postsynaptic Nicotinic Acetylcholine Receptors Pathway Diagram
 Highly Sodium Permeable Acetylcholine Nicotinic Receptors Pathway antibodies  Highly Sodium Permeable Acetylcholine Nicotinic Receptors Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway antibodies  Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway Diagram
Diseases associated with N AChR elisa kitOrgans/Tissues associated with N AChR elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >102 publications with N AChR and Nervous System Diseases
 Epilepsy, Frontal Lobe Antibodies  >65 publications with N AChR and Epilepsy, Frontal Lobe
 Seizures Antibodies  >51 publications with N AChR and Seizures
 Attention Deficit Disorder with Hyperactivity Antibodies  >15 publications with N AChR and Attention Deficit Disorder with Hyperactivity
 Sleep Disorders Antibodies  >14 publications with N AChR and Sleep Disorders
 Neurobehavioral Manifestations Antibodies  >8 publications with N AChR and Neurobehavioral Manifestations
 Dystonia Antibodies  >6 publications with N AChR and Dystonia
 Epilepsy, Nocturnal Frontal Lobe, Type 1 Antibodies  >5 publications with N AChR and Epilepsy, Nocturnal Frontal Lobe, Type 1
 Cognition Disorders Antibodies  >4 publications with N AChR and Cognition Disorders
 Learning Disorders Antibodies  >4 publications with N AChR and Learning Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >61 publications with N AChR and Brain
 Eye Antibodies  >2 publications with N AChR and Eye
 Testis Antibodies  >1 publications with N AChR and Testis
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