CAA62566.1
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,370 Da
NCBI Official Full Name
norepinephrine transporter
NCBI Official Synonym Full Names
solute carrier family 6 (neurotransmitter transporter), member 2
NCBI Protein Information
sodium-dependent noradrenaline transporter; norepinephrine transporter; neurotransmitter transporter; solute carrier family 6 member 5; solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
UniProt Protein Name
Sodium-dependent noradrenaline transporter
UniProt Synonym Protein Names
Norepinephrine transporter; NET; Solute carrier family 6 member 2
UniProt Synonym Gene Names
UniProt Entry Name
SC6A2_HUMAN
NCBI Summary for NE
This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]
UniProt Comments for NE
SLC6A2: Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals. Defects in SLC6A2 are a cause of orthostatic intolerance (OI). OI is a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. It is associated with postural tachycardia. Plasma norepinephrine concentration is abnormally high. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A2 subfamily.
Protein type: Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral; Transporter
Chromosomal Location of Human Ortholog: 16q12.2
Cellular Component: neuron projection; cell surface; membrane; integral to plasma membrane; plasma membrane; lipid raft
Molecular Function: protein binding; beta-tubulin binding; monoamine transmembrane transporter activity; alpha-tubulin binding; norephinephrine:sodium symporter activity
Biological Process: response to drug; synaptic transmission; norepinephrine transport; transport; neurotransmitter transport; monoamine transport; response to pain; transmembrane transport
Disease: Orthostatic Intolerance
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with NE elisa kit
Pathways associated with NE elisa kit
Diseases associated with NE elisa kit
Organs/Tissues associated with NE elisa kit
|