NP_937818.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
30,137 Da
NCBI Official Full Name
nucleoside diphosphate kinase A isoform a
NCBI Official Synonym Full Names
NME/NM23 nucleoside diphosphate kinase 1
NCBI Official Synonym Symbols
NB; AWD; NBS; GAAD; NDKA; NM23; NDPKA; NDPK-A; NM23-H1 [Similar Products]
NCBI Protein Information
nucleoside diphosphate kinase A
UniProt Protein Name
Nucleoside diphosphate kinase A
UniProt Synonym Protein Names
Granzyme A-activated DNase; GAAD; Metastasis inhibition factor nm23; NM23-H1; Tumor metastatic process-associated protein
UniProt Synonym Gene Names
UniProt Entry Name
NDKA_HUMAN
NCBI Summary for NME1
This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]
UniProt Comments for NME1
NME1: an enzyme with multiple activities including histidine protein kinase, nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase and 3'-5' exonuclease activities. Plays a major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Involved in cell proliferation, differentiation and development, G protein-coupled receptor endocytosis, cytotoxic T cell and NK cell-mediated cell death, and gene expression. Required for neural development including neural patterning and cell fate determination. During granzyme A (GZMA)-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. Three alternatively spliced human proteins have been reported.
Protein type: EC 2.7.4.6; Kinase, nucleoside diphosphate; Protein kinase, histidine; Nucleotide Metabolism - purine; Tumor suppressor; Kinase, other; Nucleotide Metabolism - pyrimidine; Other group; NDK family
Chromosomal Location of Human Ortholog: 17q21.3
Cellular Component: centrosome; cytoplasm; cytosol; intermediate filament; membrane; mitochondrial outer membrane; myelin sheath; nucleus; perinuclear region of cytoplasm
Molecular Function: ATP binding; deoxyribonuclease activity; gamma-tubulin binding; GTP binding; identical protein binding; intermediate filament binding; magnesium ion binding; nucleoside diphosphate kinase activity; protein binding; protein kinase binding; ribosomal small subunit binding; single-stranded DNA binding
Biological Process: CTP biosynthetic process; DNA metabolic process; endocytosis; GTP biosynthetic process; hippocampus development; lactation; negative regulation of cell proliferation; negative regulation of myeloid leukocyte differentiation; nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside and nucleotide metabolic process; nucleoside diphosphate phosphorylation; nucleoside triphosphate biosynthetic process; positive regulation of DNA binding; positive regulation of epithelial cell proliferation; purine nucleotide metabolic process; pyrimidine nucleotide metabolic process; regulation of apoptosis; response to amine stimulus; response to cAMP; response to testosterone stimulus; UTP biosynthetic process
Disease: Neuroblastoma, Susceptibility To
Research Articles on NME1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with NME1 elisa kit
Pathways associated with NME1 elisa kit
Products by Pathway |
Pathway Diagram |
Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies |
Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram |
Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies |
Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram |
Arf6 Downstream Pathway antibodies |
Arf6 Downstream Pathway Diagram |
Arf6 Trafficking Events Pathway antibodies |
Arf6 Trafficking Events Pathway Diagram |
CMP Phosphorylation Pathway antibodies |
CMP Phosphorylation Pathway Diagram |
CMP Phosphorylation Pathway antibodies |
CMP Phosphorylation Pathway Diagram |
E-cadherin Signaling In The Nascent Adherens Junction Pathway antibodies |
E-cadherin Signaling In The Nascent Adherens Junction Pathway Diagram |
Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies |
Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram |
Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies |
Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram |
Integrated Pancreatic Cancer Pathway antibodies |
Integrated Pancreatic Cancer Pathway Diagram |
Diseases associated with NME1 elisa kit
Organs/Tissues associated with NME1 elisa kit
|