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OBSCN elisa kit :: Human Obscurin (OBSCN) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9312359 OBSCN elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Obscurin (OBSCN), ELISA Kit

★Popular Item★
 Also Known As   

Human Obscurin (OBSCN) ELISA Kit

 Product Gene Name   

OBSCN elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 1; NC_000001.10 (228395831..228566575). Location: 1q42.13
 OMIM    608616
 3D Structure    ModBase 3D Structure for Q5VST9
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 Species Reactivity    Human
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    Body fluids, tissue homogenates, secretions or feces samples
 Assay Type    Quantitative Sandwich
 Detection Range    0.625 ng/ml - 20 ng/ml
 Sensitivity    0.1 ng/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of OBSCN elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for OBSCN purchase    MBS9312359 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Obscurin (OBSCN) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.625 ng/ml - 20 ng/ml in biological research samples containing OBSCN, with an estimated sensitivity of 0.1 ng/ml. The ELISA analytical biochemical technique of the MBS9312359 kit is based on OBSCN antibody-OBSCN antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect OBSCN antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, OBSCN. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Body fluids, tissue homogenates, secretions or feces samples. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for OBSCN elisa kit

   Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of OBSCN (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS9312359. Click to request current manual
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NCBI/Uniprot data below describe general gene information for OBSCN. It may not necessarily be applicable to this product.
 NCBI GI #    15026974
 NCBI GeneID    84033
 NCBI Accession #    CAC44768.1 [Other Products]
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 UniProt Primary Accession #    Q5VST9 [Other Products]
 UniProt Secondary Accession #    Q2A664; Q5T7G8; Q5T7G9; Q5VSU2; Q86YC7; Q8NHN0; Q8NHN1; Q8NHN2; Q8NHN3; Q8NHN4; Q8NHN5 [Other Products]
 UniProt Related Accession #    Q5VST9 [Other Products]
 Molecular Weight    868,484 Da
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 NCBI Official Full Name    obscurin
 NCBI Official Synonym Full Names    obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
 NCBI Official Symbol    OBSCN [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    obscurin; obscurin-MLCK; obscurin, myosin light chain kinase
 UniProt Protein Name    Obscurin
 UniProt Synonym Protein Names   
Obscurin-RhoGEF; Obscurin-myosin light chain kinase
 Protein Family    Obscurin
 UniProt Gene Name    OBSCN [Similar Products]
 UniProt Synonym Gene Names    KIAA1556; KIAA1639; Obscurin-MLCK [Similar Products]
 UniProt Entry Name    OBSCN_HUMAN
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 NCBI Summary for OBSCN    The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
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 UniProt Comments for OBSCN    OBSCN: a Ca(2+)/calmodulin-dependent protein kinase of the Trio family. A giant protein with one Rho GEF domain, one PH domain and two kinase domains. Expressed in skeletal and cardiac muscle, concentrating around Z-disks and M-lines of striated muscle. Binds ankyrin 1 interacts with sarcomeric myosin. May play a critical role in its ability to assemble into A bands in striated muscle.

Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; Kinase, protein; EC; CAMK group; Trio family

Chromosomal Location of Human Ortholog: 1q42.13

Cellular Component: myofibril; M band; Z disc; cytosol

Molecular Function: calmodulin binding; protein serine/threonine kinase activity; protein binding; Rho guanyl-nucleotide exchange factor activity; structural constituent of muscle; metal ion binding; titin binding; ankyrin binding; ATP binding

Biological Process: regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; multicellular organismal development; small GTPase mediated signal transduction; sarcomere organization; protein amino acid phosphorylation
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 Research Articles on OBSCN    1. Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with OBSCN elisa kitDiseases associated with OBSCN elisa kit
 Products by Pathway  Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 G Alpha (12/13) Signalling Events Pathway antibodies  G Alpha (12/13) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 NRAGE Signals Death Through JNK Pathway antibodies  NRAGE Signals Death Through JNK Pathway Diagram
 Regulation Of RhoA Activity Pathway antibodies  Regulation Of RhoA Activity Pathway Diagram
 Rho GTPase Cycle Pathway antibodies  Rho GTPase Cycle Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
 Signaling By Rho GTPases Pathway antibodies  Signaling By Rho GTPases Pathway Diagram
 Signalling By NGF Pathway antibodies  Signalling By NGF Pathway Diagram
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >6 publications with OBSCN and Heart Diseases
 Heart Failure Antibodies  >2 publications with OBSCN and Heart Failure
 Nervous System Diseases Antibodies  >2 publications with OBSCN and Nervous System Diseases
 Fibrosis Antibodies  >1 publications with OBSCN and Fibrosis
 Chromosome Breakage Antibodies  >1 publications with OBSCN and Chromosome Breakage
 Weight Loss Antibodies  >1 publications with OBSCN and Weight Loss
 Hypertrophy Antibodies  >1 publications with OBSCN and Hypertrophy
 Pancreatic Neoplasms Antibodies  >1 publications with OBSCN and Pancreatic Neoplasms
Organs/Tissues associated with OBSCN elisa kit
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >42 publications with OBSCN and Muscle
 Heart Antibodies  >16 publications with OBSCN and Heart
 Embryonic Tissue Antibodies  >5 publications with OBSCN and Embryonic Tissue
 Bone Antibodies  >1 publications with OBSCN and Bone
 Kidney Antibodies  >1 publications with OBSCN and Kidney
 Connective Tissue Antibodies  >1 publications with OBSCN and Connective Tissue
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