NP_954642.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
10,963 Da
NCBI Official Full Name
osteocalcin preproprotein
NCBI Official Synonym Full Names
bone gamma-carboxyglutamate (gla) protein
NCBI Official Synonym Symbols
NCBI Protein Information
osteocalcin; bone Gla protein; gamma-carboxyglutamic acid-containing protein; bone gamma-carboxyglutamate (gla) protein (osteocalcin)
UniProt Protein Name
Osteocalcin
UniProt Synonym Protein Names
Bone Gla protein; BGP; Gamma-carboxyglutamic acid-containing protein
UniProt Synonym Gene Names
UniProt Entry Name
OSTCN_HUMAN
NCBI Summary for OT/BGP
This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]
UniProt Comments for OT/BGP
osteocalcin: Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. Belongs to the osteocalcin/matrix Gla protein family.
Protein type: Cell development/differentiation; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 1q22
Cellular Component: Golgi apparatus; extracellular space; rough endoplasmic reticulum; dendrite; cytoplasm; perikaryon
Molecular Function: structural constituent of bone; hydroxyapatite binding; calcium ion binding; structural molecule activity
Biological Process: response to drug; response to gravity; regulation of bone resorption; response to glucocorticoid stimulus; cell aging; response to testosterone stimulus; bone mineralization; osteoblast development; osteoblast differentiation; odontogenesis; response to ethanol; response to vitamin D; regulation of osteoclast differentiation; response to vitamin K; response to mechanical stimulus; response to estrogen stimulus; response to zinc ion; response to hydroxyisoflavone; response to activity; cell adhesion; regulation of bone mineralization; skeletal development
Research Articles on OT/BGP
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Products associated with OT/BGP elisa kit
Pathways associated with OT/BGP elisa kit
Diseases associated with OT/BGP elisa kit
Organs/Tissues associated with OT/BGP elisa kit
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