NP_658986.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,996 Da
NCBI Official Full Name
prokineticin receptor 2
NCBI Official Synonym Full Names
prokineticin receptor 2
NCBI Official Synonym Symbols
HH3; KAL3; PKR2; GPRg2; GPR73b; GPR73L1; dJ680N4.3 [Similar Products]
NCBI Protein Information
prokineticin receptor 2; G protein-coupled receptor 73-like 1; PK-R2
UniProt Protein Name
Prokineticin receptor 2
UniProt Synonym Protein Names
G-protein coupled receptor 73-like 1; GPR73b; GPRg2
UniProt Synonym Gene Names
UniProt Entry Name
PKR2_HUMAN
NCBI Summary for PKR2
Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins. [provided by RefSeq, Jul 2008]
UniProt Comments for PKR2
PROKR2: Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. Defects in PROKR2 are the cause of Kallmann syndrome type 3 (KAL3); also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin- releasing hormone-synthesizing neurons. KAL3 patients have variable degrees of olfactory and reproductive dysfunction, but do not show any of the occasional clinical anomalies reported in Kallmann syndrome such as renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR
Chromosomal Location of Human Ortholog: 20p12.3
Cellular Component: integral to membrane; plasma membrane
Molecular Function: neuropeptide Y receptor activity
Biological Process: circadian rhythm; neuropeptide signaling pathway
Disease: Hypogonadotropic Hypogonadism 3 With Or Without Anosmia
Research Articles on PKR2
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Products associated with PKR2 elisa kit
Pathways associated with PKR2 elisa kit
Diseases associated with PKR2 elisa kit
Organs/Tissues associated with PKR2 elisa kit
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