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PLCgamma1 elisa kit :: Human PLCgamma1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2505694
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PLCgamma1, ELISA Kit

★Popular Item★
 Also Known As   

Human PLCgamma1 (Phospholipase C Gamma 1) ELISA Kit

 Product Gene Name   

PLCgamma1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    172420
 3D Structure    ModBase 3D Structure for P19174
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Human PLCgamma1. No significant cross-reactivity or interference between Human PLCgamma1 and analogues was observed. Note: Limited by current skills and knowledge, it is impossible for us to complete the cross- reactivity detection between Human PLCgamma1 and all the analogues, therefore, cross reaction may still exist.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    0.156--10ng/mL
 Sensitivity    0.094ng/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PLCgamma1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PLCgamma1 purchase    MBS2505694 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the PLCgamma1, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.156--10ng/mL in biological research samples containing PLCgamma1, with an estimated sensitivity of 0.094ng/mL. The ELISA analytical biochemical technique of the MBS2505694 kit is based on PLCgamma1 antibody-PLCgamma1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PLCgamma1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PLCgamma1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for PLCgamma1 elisa kit

   Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of PLCgamma1 in human serum, plasma and other biological fluids
Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human PLCgamma1. Standards or samples are added to the appropriate micro ELISA plate wells and bound by the specific antibody. Then a biotinylated detection antibody specific for Human PLCgamma1 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human PLCgamma1, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Human PLCgamma1. You can calculate the concentration of Human PLCgamma1 in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of PLCgamma1 elisa kit    PLCgamma1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2505694. Click to request current manual
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NCBI/Uniprot data below describe general gene information for PLCgamma1. It may not necessarily be applicable to this product.
 NCBI GI #    223459640
 NCBI GeneID    5335
 NCBI Accession #    AAI36467.1 [Other Products]
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 UniProt Primary Accession #    P19174 [Other Products]
 UniProt Secondary Accession #    Q2V575; B7ZLY7; B9EGH4; E1P5W4 [Other Products]
 UniProt Related Accession #    P19174 [Other Products]
 Molecular Weight    148,660 Da
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 NCBI Official Full Name    Phospholipase C, gamma 1
 NCBI Official Synonym Full Names    phospholipase C, gamma 1
 NCBI Official Symbol    PLCG1 [Similar Products]
 NCBI Official Synonym Symbols   
PLC1; NCKAP3; PLC-II; PLC148; PLCgamma1
[Similar Products]
 NCBI Protein Information    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1; PLC-148; PLC-gamma-1; inositoltrisphosphohydrolase; monophosphatidylinositol phosphodiesterase; phosphatidylinositol phospholipase C; phosphoinositidase C; phosphoinositide phospholipase C; phosphoinositide phospholipase C-gamma-1; phospholipase C, gamma 1 (formerly subtype 148); phospholipase C-148; phospholipase C-II; triphosphoinositide phosphodiesterase
 UniProt Protein Name    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
 UniProt Synonym Protein Names   
PLC-148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; PLC-II; Phospholipase C-gamma-1; PLC-gamma-1
 UniProt Gene Name    PLCG1 [Similar Products]
 UniProt Synonym Gene Names    PLC1; PLC-II; PLC-gamma-1 [Similar Products]
 UniProt Entry Name    PLCG1_HUMAN
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 NCBI Summary for PLCgamma1    The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PLCgamma1    PLCG1: a calcium dependent phosphatidylinositol-specific phospholipase C. The activated enzyme produces the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylated and activated by tyrosine kinases in response to signaling through a variety of growth factor receptors and immune system receptors.

Protein type: Phospholipase; Motility/polarity/chemotaxis; EC 3.1.4.11; Carbohydrate Metabolism - inositol phosphate

Chromosomal Location of Human Ortholog: 20q12-q13.1

Cellular Component: signalosome; ruffle; cell projection; lamellipodium; cytoplasm; plasma membrane; intercellular junction; cytosol

Molecular Function: protein binding; glutamate receptor binding; neurotrophin TRKA receptor binding; receptor signaling protein activity; calcium ion binding; receptor tyrosine kinase binding; phospholipase C activity; phosphoinositide phospholipase C activity; protein kinase binding

Biological Process: epidermal growth factor receptor signaling pathway; axon guidance; cell migration; fibroblast growth factor receptor signaling pathway; inositol phosphate metabolic process; nerve growth factor receptor signaling pathway; viral reproduction; activation of MAPKK activity; in utero embryonic development; phospholipid catabolic process; cytokine and chemokine mediated signaling pathway; positive regulation of blood vessel endothelial cell migration; calcium-mediated signaling; signal transduction; T cell receptor signaling pathway; positive regulation of angiogenesis; phospholipase C activation; innate immune response; positive regulation of release of sequestered calcium ion into cytosol; vascular endothelial growth factor receptor signaling pathway; blood coagulation; leukocyte migration
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 Research Articles on PLCgamma1    1. The activation of the gamma1 isoform of phospholipase C (PLCgamma1) is critical for pressure sensing in cerebral arteries and subsequent vasoconstriction.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PLCgamma1 elisa kitPathways associated with PLCgamma1 elisa kit
 Reference Product  PubMed Publications
 LAT elisa kit  >5 publications with PLCgamma1 and LAT
 GRB2 elisa kit  >4 publications with PLCgamma1 and GRB2
 EGFR elisa kit  >4 publications with PLCgamma1 and EGFR
 SOS1 elisa kit  >2 publications with PLCgamma1 and SOS1
 FGFR1 elisa kit  >2 publications with PLCgamma1 and FGFR1
 NTRK1 elisa kit  >1 publications with PLCgamma1 and NTRK1
 CBL elisa kit  >1 publications with PLCgamma1 and CBL
 PDGFRB elisa kit  >1 publications with PLCgamma1 and PDGFRB
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
Diseases associated with PLCgamma1 elisa kitOrgans/Tissues associated with PLCgamma1 elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >7 publications with PLCgamma1 and Inflammation
 Cardiovascular Diseases Antibodies  >5 publications with PLCgamma1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >3 publications with PLCgamma1 and Heart Diseases
 Necrosis Antibodies  >3 publications with PLCgamma1 and Necrosis
 Disease Models, Animal Antibodies  >2 publications with PLCgamma1 and Disease Models, Animal
 Brain Diseases Antibodies  >2 publications with PLCgamma1 and Brain Diseases
 Hemangiosarcoma Antibodies  >2 publications with PLCgamma1 and Hemangiosarcoma
 Prenatal Injuries Antibodies  >1 publications with PLCgamma1 and Prenatal Injuries
 Seizures Antibodies  >1 publications with PLCgamma1 and Seizures
 Liver Diseases Antibodies  >1 publications with PLCgamma1 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >21 publications with PLCgamma1 and Blood
 Vascular Antibodies  >11 publications with PLCgamma1 and Vascular
 Brain Antibodies  >8 publications with PLCgamma1 and Brain
 Liver Antibodies  >7 publications with PLCgamma1 and Liver
 Bone Antibodies  >7 publications with PLCgamma1 and Bone
 Muscle Antibodies  >7 publications with PLCgamma1 and Muscle
 Heart Antibodies  >5 publications with PLCgamma1 and Heart
 Lung Antibodies  >3 publications with PLCgamma1 and Lung
 Kidney Antibodies  >3 publications with PLCgamma1 and Kidney
 Skin Antibodies  >3 publications with PLCgamma1 and Skin
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