NP_001186907.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
32,970 Da
NCBI Official Full Name
phospholipid scramblase 2 isoform 1
NCBI Official Synonym Full Names
phospholipid scramblase 2
NCBI Protein Information
phospholipid scramblase 2; PL scramblase 2; ca(2+)-dependent phospholipid scramblase 2
UniProt Protein Name
Phospholipid scramblase 2
UniProt Synonym Protein Names
Ca(2+)-dependent phospholipid scramblase 2
UniProt Synonym Gene Names
UniProt Entry Name
PLS2_HUMAN
NCBI Summary for PLSCR2
This gene encodes a member of the phospholipid scramblase family. Phospholipid scramblases are membrane proteins that mediate calcium-dependent, non-specific movement of plasma membrane phospholipids and phosphatidylserine exposure. The encoded protein contains a low affinity calcium binding motif and may play a role in blood coagulation and apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
UniProt Comments for PLSCR2
PLSCR2: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Belongs to the phospholipid scramblase family.
Chromosomal Location of Human Ortholog: 3q24
Cellular Component: plasma membrane; integral to membrane; nucleus
Molecular Function: phospholipid scramblase activity; calcium ion binding
Biological Process: phospholipid scrambling
Research Articles on PLSCR2
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Diseases associated with PLSCR2 elisa kit
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