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PTD elisa kit :: Human PTD ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2505433 PTD elisa kit
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PTD, ELISA Kit

 Also Known As   

Human PTD (Pentosidine) ELISA Kit

 Product Gene Name   

PTD elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Manual Insert    Download PDF Manual View PDF Manual
 MBS2505433 COA    COA PDF
 OMIM    124000
 3D Structure    ModBase 3D Structure for Q9Y276
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 Species Reactivity    Human
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 Specificity    This kit recognizes natural and recombinant Human PTD. No significant cross-reactivity or interference between Human PTD and analogues was observed.
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 Samples    Serum, plasma and other biological fluids.
 Assay Type    Competitive
 Detection Range    6.25-400ng/mL
 Sensitivity    The minimum detectable dose of Human PTD is 3.75ng/mL (The sensitivity of this assay, or lowest detectable limit (LDL) was defined as the lowest protein concentration that could be differentiated from zero).
 Intended Uses    This ELISA kit applies to the in vitro quantitative determination of Human PTD concentrations in serum, plasma and other biological fluids.
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 Preparation and Storage    Store at 4 degree C.
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of PTD elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PTD purchase    MBS2505433 is a ready-to-use microwell, strip plate Competitive ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the PTD, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 6.25-400ng/mL in biological research samples containing PTD, with an estimated sensitivity of The minimum detectable dose of Human PTD is 3.75ng/mL (The sensitivity of this assay, or lowest detectable limit (LDL) was defined as the lowest protein concentration that could be differentiated from zero). The ELISA analytical biochemical technique of the MBS2505433 kit is based on PTD antibody-PTD antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PTD antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PTD. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma and other biological fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for PTD elisa kit

   Principle of the Assay: This ELISA kit uses Competitive-ELISA as the method. The microtiter plate provided in this kit has been pre-coated with PTD. During the reaction, PTD in the sample or standard competes with a fixed amount of PTD on the solid phase supporter for sites on the Biotinylated Detection Ab specific to PTD. Excess conjugate and unbound sample or standard are washed from the plate, and Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then a TMB substrate solution is added to each well. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The concentration of PTD in the samples is then determined by comparing the OD of the samples to the standard curve.
Sample Manual Insert of MBS2505433
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NCBI/Uniprot data below describe general gene information for PTD. It may not necessarily be applicable to this product.
 NCBI GI #    578804710
 NCBI GeneID    617
 NCBI Accession #    XP_006712741.1 [Other Products]
 NCBI GenBank Nucleotide #    XM_006712678.1 [Other Products]
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 UniProt Primary Accession #    Q9Y276 [Other Products]
 UniProt Secondary Accession #    Q7Z2V7; B3KTW9 [Other Products]
 UniProt Related Accession #    Q9Y276 [Other Products]
 Molecular Weight    47,534 Da
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 NCBI Official Full Name    PREDICTED: mitochondrial chaperone BCS1 isoform X4
 NCBI Official Synonym Full Names    BC1 (ubiquinol-cytochrome c reductase) synthesis-like
 NCBI Official Symbol    BCS1L [Similar Products]
 NCBI Official Synonym Symbols   
BCS; BJS; PTD; BCS1; FLNMS; h-BCS; MC3DN1; GRACILE; Hs.6719
[Similar Products]
 NCBI Protein Information    mitochondrial chaperone BCS1; BCS1-like protein; h-BCS1; mitochondrial complex III assembly
 UniProt Protein Name    Mitochondrial chaperone BCS1
 UniProt Synonym Protein Names   
BCS1-like protein
 UniProt Gene Name    BCS1L [Similar Products]
 UniProt Synonym Gene Names    BCS1; h-BCS1 [Similar Products]
 UniProt Entry Name    BCS1_HUMAN
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 NCBI Summary for PTD    This gene encodes a homolog of the S. cerevisiae bcs1 protein which is involved in the assembly of complex III of the mitochondrial respiratory chain. The encoded protein does not contain a mitochondrial targeting sequence but experimental studies confirm that it is imported into mitochondria. Mutations in this gene are associated with mitochondrial complex III deficiency and the GRACILE syndrome. Five alternatively spliced transcripts encoding the same protein have been described. [provided by RefSeq, Mar 2012]
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 UniProt Comments for PTD    BCS1L: Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. Defects in BCS1L are the cause of GRACILE syndrome (GRACILE). GRACILE stands for 'growth retardation, aminoaciduria, cholestasis, iron overload, lactic acidosis, and early death'. It is a recessively inherited lethal disease characterized by fetal growth retardation, lactic acidosis, aminoaciduria, cholestasis, and abnormalities in iron metabolism. Defects in BCS1L are a cause of mitochondrial complex III deficiency (MT-C3D). A disorder of the mitochondrial respiratory chain resulting in a highly variable phenotype depending on which tissues are affected. Clinical features include mitochondrial encephalopathy, psychomotor retardation, ataxia, severe failure to thrive, liver dysfunction, renal tubulopathy, muscle weakness and exercise intolerance. Defects in BCS1L are the cause of Bjoernstad syndrome (BJS). BJS is an autosomal recessive condition characterized by sensorineural hearing loss and pili torti. The hearing loss in BJS is congenital and of variable severity. Pili torti (twisted hairs), a condition in which the hair shafts are flattened at irregular intervals and twisted 180 degrees from the normal axis, making the hair extremely brittle, is usually recognized early in childhood. Belongs to the AAA ATPase family. BCS1 subfamily.

Protein type: Membrane protein, integral; Chaperone; Mitochondrial

Chromosomal Location of Human Ortholog: 2q33

Cellular Component: mitochondrion; mitochondrial respiratory chain complex III

Molecular Function: protein binding; ATP binding

Biological Process: mitochondrion organization and biogenesis; mitochondrial respiratory chain complex I assembly; mitochondrial respiratory chain complex IV assembly

Disease: Leigh Syndrome; Gracile Syndrome; Bjornstad Syndrome; Mitochondrial Complex Iii Deficiency, Nuclear Type 1
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 Research Articles on PTD    1. A novel behavioral and psychiatric phenotype associated with a p.Gly129Arg BCS1L mutation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PTD elisa kitPathways associated with PTD elisa kit
 Reference Product  PubMed Publications
 LETM1 elisa kit  >1 publications with PTD and LETM1
 UQCRFS1 elisa kit  >1 publications with PTD and UQCRFS1
 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Mitochondrial Protein Import Pathway antibodies  Mitochondrial Protein Import Pathway Diagram
Diseases associated with PTD elisa kitOrgans/Tissues associated with PTD elisa kit
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >13 publications with PTD and Liver Diseases
 Fetal Growth Retardation Antibodies  >8 publications with PTD and Fetal Growth Retardation
 Kidney Diseases Antibodies  >7 publications with PTD and Kidney Diseases
 Mitochondrial Complex III Deficiency Antibodies  >7 publications with PTD and Mitochondrial Complex III Deficiency
 Fetal Death Antibodies  >6 publications with PTD and Fetal Death
 Bjornstad syndrome Antibodies  >6 publications with PTD and Bjornstad syndrome
 Liver Cirrhosis Antibodies  >4 publications with PTD and Liver Cirrhosis
 Finnish lethal neonatal metabolic syndrome Antibodies  >3 publications with PTD and Finnish lethal neonatal metabolic syndrome
 Inflammation Antibodies  >2 publications with PTD and Inflammation
 Fibrosis Antibodies  >2 publications with PTD and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >20 publications with PTD and Liver
 Muscle Antibodies  >6 publications with PTD and Muscle
 Kidney Antibodies  >5 publications with PTD and Kidney
 Brain Antibodies  >5 publications with PTD and Brain
 Blood Antibodies  >4 publications with PTD and Blood
 Ganglia Antibodies  >3 publications with PTD and Ganglia
 Heart Antibodies  >3 publications with PTD and Heart
 Embryonic Tissue Antibodies  >2 publications with PTD and Embryonic Tissue
 Skin Antibodies  >2 publications with PTD and Skin
 Testis Antibodies  >1 publications with PTD and Testis
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