NP_000933.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23,743 Da
NCBI Official Full Name
peptidyl-prolyl cis-trans isomerase B
NCBI Official Synonym Full Names
peptidylprolyl isomerase B
NCBI Official Synonym Symbols
OI9; CYPB; SCYLP; CYP-S1; HEL-S-39 [Similar Products]
NCBI Protein Information
peptidyl-prolyl cis-trans isomerase B
UniProt Protein Name
Peptidyl-prolyl cis-trans isomerase B
UniProt Synonym Protein Names
CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLP
UniProt Synonym Gene Names
UniProt Entry Name
PPIB_HUMAN
NCBI Summary for PPIB
The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]
UniProt Comments for PPIB
PPIB: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Defects in PPIB are the cause of osteogenesis imperfecta type 9 (OI9). OI9 is a connective tissue disorder characterized by bone fragility, low bone mass and bowing of limbs due to multiple fractures. Short limb dwarfism and blue sclerae are observed in some but not all patients. Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.
Protein type: Chaperone; RNA-binding; Secreted, signal peptide; Isomerase; Cyclophilin; EC 5.2.1.8; Secreted
Chromosomal Location of Human Ortholog: 15q21-q22
Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen; focal adhesion; melanosome; membrane; nucleus; perinuclear region of cytoplasm; smooth endoplasmic reticulum
Molecular Function: collagen binding; peptide binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; protein complex binding; unfolded protein binding
Biological Process: extracellular matrix organization and biogenesis; positive regulation of multicellular organism growth; protein peptidyl-prolyl isomerization; protein stabilization
Disease: Osteogenesis Imperfecta, Type Ix
Research Articles on PPIB
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Products associated with PPIB elisa kit
Pathways associated with PPIB elisa kit
Diseases associated with PPIB elisa kit
Organs/Tissues associated with PPIB elisa kit
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