NP_001182662.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
70,214 Da
NCBI Official Full Name
phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform 1
NCBI Official Synonym Full Names
phosphatidylinositol-4-phosphate 5-kinase type 1 gamma
NCBI Official Synonym Symbols
LCCS3; PIP5Kgamma; PIP5K-GAMMA; PIP5K1-gamma [Similar Products]
NCBI Protein Information
phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
UniProt Protein Name
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
UniProt Synonym Protein Names
Phosphatidylinositol 4-phosphate 5-kinase type I gamma; PIP5KIgamma
UniProt Synonym Gene Names
KIAA0589; PIP5K1-gamma; PtdIns(4)P-5-kinase 1 gamma; PIP5KIgamma [Similar Products]
NCBI Summary for PIP5K1C
This locus encodes a type I phosphatidylinositol 4-phosphate 5-kinase. The encoded protein catalyzes phosphorylation of phosphatidylinositol 4-phosphate, producing phosphatidylinositol 4,5-bisphosphate. This enzyme is found at synapses and has been found to play roles in endocytosis and cell migration. Mutations at this locus have been associated with lethal congenital contractural syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Sep 2010]
UniProt Comments for PIP5K1C
PIP5K1C: a member of the type I phosphatidylinositol-4-phosphate 5-kinase family of enzymes. A similar protein in mice is found in synapses and focal adhesion plaques, and binds the FERM domain of talin through its C-terminus.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: cytosol; endosome membrane; focal adhesion; nucleoplasm; phagocytic cup; presynapse; uropod
Molecular Function: 1-phosphatidylinositol-4-phosphate 5-kinase activity; ATP binding; protein binding
Biological Process: actin cytoskeleton organization; clathrin-dependent endocytosis; neutrophil chemotaxis; phagocytosis; phosphatidylinositol biosynthetic process; phosphatidylinositol phosphorylation; regulation of phosphatidylinositol 3-kinase signaling; synaptic vesicle endocytosis; synaptic vesicle exocytosis
Disease: Lethal Congenital Contracture Syndrome 3
Research Articles on PIP5K1C
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Pathways associated with PIP5K1C elisa kit
Diseases associated with PIP5K1C elisa kit
Organs/Tissues associated with PIP5K1C elisa kit
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