NP_001164056.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47,341 Da
NCBI Official Full Name
phospholipase B1, membrane-associated isoform 2
NCBI Official Synonym Full Names
phospholipase B1
NCBI Official Synonym Symbols
NCBI Protein Information
phospholipase B1, membrane-associated
UniProt Protein Name
Phospholipase B1, membrane-associated
UniProt Synonym Protein Names
Phospholipase B/lipase; PLB/LIP
UniProt Synonym Gene Names
NCBI Summary for PLB1
This gene encodes a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the enzyme to the membrane and a short C-terminal cytoplasmic tail. This gene has been identified as a candidate rheumatoid arthritis risk gene. [provided by RefSeq, Jul 2016]
UniProt Comments for PLB1
PLB1: Membrane-associated phospholipase. Exhibits a calcium- independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids. Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.1.1.4; EC 3.1.1.5; Membrane protein, integral; Phospholipase
Chromosomal Location of Human Ortholog: 2p23.2
Cellular Component: apical plasma membrane; integral component of membrane; plasma membrane
Molecular Function: lysophospholipase activity; phospholipase A2 activity; retinyl-palmitate esterase activity
Biological Process: lipid catabolic process; retinoid metabolic process; retinol metabolic process
Research Articles on PLB1
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Products associated with PLB1 elisa kit
Pathways associated with PLB1 elisa kit
Diseases associated with PLB1 elisa kit
Organs/Tissues associated with PLB1 elisa kit
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