NP_002644.4
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
34,128 Da
NCBI Official Full Name
pituitary homeobox 1
NCBI Official Synonym Full Names
paired like homeodomain 1
NCBI Protein Information
pituitary homeobox 1
UniProt Protein Name
Pituitary homeobox 1
UniProt Synonym Protein Names
Hindlimb-expressed homeobox protein backfoot; Homeobox protein PITX1; Paired-like homeodomain transcription factor 1
UniProt Synonym Gene Names
NCBI Summary for PITX1
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. [provided by RefSeq, Jul 2008]
UniProt Comments for PITX1
PITX1: May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. Defects in PITX1 are a cause of congenital clubfoot (CCF); also known as talipes equinovarus (TEV). Clubfoot is a congenital limb deformity defined as fixation of the foot in cavus, adductus, varus, and equinus (i.e. inclined inwards, axially rotated outwards, and pointing downwards) with concomitant soft tissue abnormalities. Clubfoot may occur in isolation or as part of a syndrome. Clubfoot appears to be a multifactorial trait. Belongs to the paired homeobox family. Bicoid subfamily.
Protein type: Cell development/differentiation; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: cytoplasm; nucleolus; nucleus; transcription factor complex
Molecular Function: DNA binding transcription factor activity; protein binding
Biological Process: anatomical structure morphogenesis; branchiomeric skeletal muscle development; cartilage development; embryonic hindlimb morphogenesis; myoblast cell fate commitment; negative regulation of transcription, DNA-dependent; pituitary gland development; positive regulation of transcription from RNA polymerase II promoter; skeletal system development; transcription from RNA polymerase II promoter
Disease: Clubfoot, Congenital, With Or Without Deficiency Of Long Bones And/or Mirror-image Polydactyly; Liebenberg Syndrome
Research Articles on PITX1
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Products associated with PITX1 elisa kit
Diseases associated with PITX1 elisa kit
Organs/Tissues associated with PITX1 elisa kit
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