NP_001165806.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
70,811 Da
NCBI Official Full Name
plastin-3 isoform 2
NCBI Official Synonym Full Names
plastin 3
NCBI Official Synonym Symbols
NCBI Protein Information
plastin-3; T fimbrin; T plastin
UniProt Protein Name
Plastin-3
UniProt Synonym Protein Names
T-plastin
UniProt Entry Name
PLST_HUMAN
NCBI Summary for PLS3
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]
UniProt Comments for PLS3
PLS3: Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: Xq23
Cellular Component: cytoplasm
Molecular Function: calcium ion binding; actin binding
Disease: Bone Mineral Density Quantitative Trait Locus 18
Research Articles on PLS3
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Products associated with PLS3 elisa kit
Diseases associated with PLS3 elisa kit
Organs/Tissues associated with PLS3 elisa kit
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