AAI27771.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
205,127 Da
NCBI Official Full Name
PLXNB2 protein
NCBI Official Synonym Full Names
plexin B2
NCBI Official Synonym Symbols
MM1; PLEXB2; Nbla00445; dJ402G11.3 [Similar Products]
NCBI Protein Information
plexin-B2
UniProt Protein Name
Plexin-B2
UniProt Synonym Protein Names
MM1
UniProt Synonym Gene Names
UniProt Entry Name
PLXB2_HUMAN
NCBI Summary for PLXNB2
Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008]
UniProt Comments for PLXNB2
PLXNB2: Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound- healing assays (in vitro). Belongs to the plexin family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 22q13.33
Cellular Component: cell surface; integral to plasma membrane; intracellular
Molecular Function: protein binding; semaphorin receptor activity
Biological Process: regulation of cell shape; regulation of protein amino acid phosphorylation; neuroblast proliferation; neural tube closure; positive regulation of axonogenesis; brain development
Research Articles on PLXNB2
Precautions
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Products associated with PLXNB2 elisa kit
Pathways associated with PLXNB2 elisa kit
Organs/Tissues associated with PLXNB2 elisa kit
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