NP_005384.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
206,847 Da
NCBI Official Full Name
plexin-B3 isoform 1
NCBI Official Synonym Full Names
plexin B3
NCBI Protein Information
plexin-B3; plexin 6
UniProt Protein Name
Plexin-B3
UniProt Synonym Gene Names
UniProt Entry Name
PLXB3_HUMAN
NCBI Summary for PLXNB3
The protein encoded by this gene is a member of the plexin family. It functions as a receptor for semaphorin 5A, and plays a role in axon guidance, invasive growth and cell migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
UniProt Comments for PLXNB3
PLXNB3: Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. Belongs to the plexin family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: integral to membrane; plasma membrane; intracellular
Molecular Function: protein domain specific binding; protein binding; semaphorin receptor activity; Rho GDP-dissociation inhibitor binding
Biological Process: axon guidance; positive chemotaxis; positive regulation of endothelial cell proliferation; negative regulation of cell adhesion; negative regulation of cell migration
Research Articles on PLXNB3
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Products associated with PLXNB3 elisa kit
Pathways associated with PLXNB3 elisa kit
Diseases associated with PLXNB3 elisa kit
Organs/Tissues associated with PLXNB3 elisa kit
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