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PBRM1 elisa kit :: Human Polybromo 1 (PBRM1) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9312028 PBRM1 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Polybromo 1 (PBRM1), ELISA Kit

 Also Known As   

Human Polybromo 1 (PBRM1) ELISA Kit

 Product Gene Name   

PBRM1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 3; NC_000003.11 (52579368..52719866, complement). Location: 3p21
 OMIM    144700
 3D Structure    ModBase 3D Structure for Q86U86
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 Species Reactivity    Human
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PBRM1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PBRM1 purchase    MBS9312028 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Polybromo 1 (PBRM1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PBRM1. The ELISA analytical biochemical technique of the MBS9312028 kit is based on PBRM1 antibody-PBRM1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PBRM1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PBRM1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for PBRM1. It may not necessarily be applicable to this product.
 NCBI GI #    93102371
 NCBI GeneID    55193
 NCBI Accession #    NP_060783.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_018313.4 [Other Products]
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 UniProt Primary Accession #    Q86U86 [Other Products]
 UniProt Secondary Accession #    Q1RMD1; Q1RMD2; Q96MS2; Q9H2T3; Q9H2T4; Q9H2T5; Q9H301; Q9H314; A1L381; A1L382; A4FUJ7 [Other Products]
 UniProt Related Accession #    Q86U86 [Other Products]
 Molecular Weight    192,948 Da
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 NCBI Official Full Name    protein polybromo-1
 NCBI Official Synonym Full Names    polybromo 1
 NCBI Official Symbol    PBRM1 [Similar Products]
 NCBI Official Synonym Symbols   
PB1; BAF180
[Similar Products]
 NCBI Protein Information    protein polybromo-1; polybromo-1D; BRG1-associated factor 180
 UniProt Protein Name    Protein polybromo-1
 UniProt Synonym Protein Names   
BRG1-associated factor 180; BAF180; Polybromo-1D
 Protein Family    Protein polybromo
 UniProt Gene Name    PBRM1 [Similar Products]
 UniProt Synonym Gene Names    BAF180; PB1; hPB1; BAF180 [Similar Products]
 UniProt Entry Name    PB1_HUMAN
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 NCBI Summary for PBRM1    This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma. [provided by RefSeq, Feb 2012]
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 UniProt Comments for PBRM1    polybromo 1: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation. Defects in PBRM1 are a cause of renal cell carcinoma (RCC). It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. 9 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Tumor suppressor

Chromosomal Location of Human Ortholog: 3p21

Cellular Component: kinetochore; nuclear chromosome

Molecular Function: protein binding; DNA binding; chromatin binding

Biological Process: chromatin remodeling; mitosis; negative regulation of cell proliferation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; heart development; placenta development
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 Research Articles on PBRM1    1. The median overall survival in the UTSW cohort was significantly shorter for patients with BAP1-mutant tumours (4.6 years; 95% CI 2.1-7.2), than for patients with PBRM1-mutant tumours (10.6 years; 9.8-11.5).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with PBRM1 elisa kitOrgans/Tissues associated with PBRM1 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >22 publications with PBRM1 and Neoplasms
 Carcinoma, Renal Cell Antibodies  >18 publications with PBRM1 and Carcinoma, Renal Cell
 Kidney Diseases Antibodies  >12 publications with PBRM1 and Kidney Diseases
 Inflammation Antibodies  >3 publications with PBRM1 and Inflammation
 Congenital Abnormalities Antibodies  >2 publications with PBRM1 and Congenital Abnormalities
 Breast Neoplasms Antibodies  >2 publications with PBRM1 and Breast Neoplasms
 Heart Defects, Congenital Antibodies  >1 publications with PBRM1 and Heart Defects, Congenital
 Cell Transformation, Neoplastic Antibodies  >1 publications with PBRM1 and Cell Transformation, Neoplastic
 Liver Neoplasms Antibodies  >1 publications with PBRM1 and Liver Neoplasms
 Lung Neoplasms Antibodies  >1 publications with PBRM1 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >14 publications with PBRM1 and Kidney
 Heart Antibodies  >2 publications with PBRM1 and Heart
 Lung Antibodies  >2 publications with PBRM1 and Lung
 Embryonic Tissue Antibodies  >2 publications with PBRM1 and Embryonic Tissue
 Prostate Antibodies  >1 publications with PBRM1 and Prostate
 Thymus Antibodies  >1 publications with PBRM1 and Thymus
 Muscle Antibodies  >1 publications with PBRM1 and Muscle
 Liver Antibodies  >1 publications with PBRM1 and Liver
 Placenta Antibodies  >1 publications with PBRM1 and Placenta
 Nerve Antibodies  >1 publications with PBRM1 and Nerve
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