AAH08800.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
123,631 Da
NCBI Official Full Name
Polymerase (DNA directed), delta 1, catalytic subunit 125kDa
NCBI Official Synonym Full Names
polymerase (DNA directed), delta 1, catalytic subunit
NCBI Protein Information
DNA polymerase delta catalytic subunit
UniProt Protein Name
DNA polymerase delta catalytic subunit
UniProt Synonym Protein Names
DNA polymerase subunit delta p125
UniProt Synonym Gene Names
UniProt Entry Name
DPOD1_HUMAN
NCBI Summary for POLd
This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Mar 2012]
UniProt Comments for POLd
POLD1: Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex. Belongs to the DNA polymerase type-B family.
Protein type: Nucleotide Metabolism - pyrimidine; Hydrolase; DNA repair, damage; Transferase; Nucleotide Metabolism - purine; DNA replication; EC 2.7.7.7
Chromosomal Location of Human Ortholog: 19q13.3
Cellular Component: delta DNA polymerase complex; nucleoplasm; nucleotide-excision repair complex; membrane; cytoplasm; nucleus
Molecular Function: protein binding; DNA binding; 4 iron, 4 sulfur cluster binding; metal ion binding; 3'-5'-exodeoxyribonuclease activity; DNA-directed DNA polymerase activity; nucleotide binding; chromatin binding
Biological Process: mismatch repair; DNA strand elongation during DNA replication; DNA repair; base-excision repair, gap-filling; telomere maintenance via semi-conservative replication; DNA synthesis during DNA repair; DNA replication proofreading; base-excision repair; nucleotide-excision repair; fatty acid homeostasis; transcription-coupled nucleotide-excision repair; telomere maintenance via recombination; mitotic cell cycle; nucleotide-excision repair, DNA gap filling; DNA catabolic process, exonucleolytic; DNA replication; telomere maintenance; response to UV
Disease: Mandibular Hypoplasia, Deafness, Progeroid Features, And Lipodystrophy Syndrome; Colorectal Cancer, Susceptibility To, 10
Research Articles on POLd
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Products associated with POLd elisa kit
Pathways associated with POLd elisa kit
Diseases associated with POLd elisa kit
Organs/Tissues associated with POLd elisa kit
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