NP_001258932.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
136,987 Da
NCBI Official Full Name
potassium channel subfamily T member 1 isoform 2
NCBI Official Synonym Full Names
potassium sodium-activated channel subfamily T member 1
NCBI Official Synonym Symbols
ENFL5; SLACK; EIEE14; KCa4.1; Slo2.2; bA100C15.2 [Similar Products]
NCBI Protein Information
potassium channel subfamily T member 1
UniProt Protein Name
Potassium channel subfamily T member 1
UniProt Synonym Protein Names
KCa4.1
UniProt Synonym Gene Names
NCBI Summary for KCNT1
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
UniProt Comments for KCNT1
KCNT1: Outwardly rectifying potassium channel subunit that may co-assemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro). Belongs to the potassium channel family. Calcium- activated (TC 1.A.1.3) subfamily. KCa4.1/KCNT1 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 9q34.3
Cellular Component: voltage-gated potassium channel complex
Molecular Function: calcium-activated potassium channel activity; voltage-gated potassium channel activity
Disease: Epilepsy, Nocturnal Frontal Lobe, 5; Epileptic Encephalopathy, Early Infantile, 14
Research Articles on KCNT1
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Diseases associated with KCNT1 elisa kit
Organs/Tissues associated with KCNT1 elisa kit
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