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KCNA4 elisa kit :: Human Potassium voltage-gated channel subfamily A member 4 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS282048 KCNA4 elisa kit
Unit / Price
48-Strip-Wells  /  $425 +1 FREE 8GB USB
96-Strip-Wells  /  $720 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,160 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,055 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Potassium voltage-gated channel subfamily A member 4 (KCNA4), ELISA Kit

 Also Known As   

Human Potassium voltage-gated channel subfamily A member 4 (KCNA4) ELISA Kit

 Product Gene Name   

KCNA4 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    M55514 mRNA
 3D Structure    ModBase 3D Structure for P22459
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Human KCNA4. No significant cross-reactivity or interference between Human KCNA4 and analogues was observed.
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 Samples    Serum, Plasma, Other biological fluids
 Assay Type    Sandwich
 Sample Volume    1-200 uL
 Precision    Intra-assay Precision (Precision within an assay)
Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Inter-assay Precision (Precision between assays)
Three samples of known concentration were tested in forty separate assays to assess inter-assay precision.
CV (%) = SD/meanX100
Intra-Assay: CV
Inter-Assay: CV
 Detection Wavelength    450 nm
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 Preparation and Storage    Store at 2-8 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of KCNA4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for KCNA4 purchase    MBS282048 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Potassium voltage-gated channel subfamily A member 4 (KCNA4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing KCNA4. The ELISA analytical biochemical technique of the MBS282048 kit is based on KCNA4 antibody-KCNA4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect KCNA4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, KCNA4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Other biological fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for KCNA4 elisa kit

   Principle of the Assay: This assay employs a two-site sandwich ELISA to quantitate KCNA4 in samples. An antibody specific for KCNA4 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyKCNA4 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for KCNA4 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of KCNA4 bound in the initial step. The color development is stopped and the intensity of the color is measured.
NCBI/Uniprot data below describe general gene information for KCNA4. It may not necessarily be applicable to this product.
 NCBI GI #    4504817
 NCBI GeneID    3739
 NCBI Accession #    NP_002224.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002233.3 [Other Products]
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 UniProt Primary Accession #    P22459 [Other Products]
 UniProt Related Accession #    P22459 [Other Products]
 Molecular Weight    73,257 Da
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 NCBI Official Full Name    potassium voltage-gated channel subfamily A member 4
 NCBI Official Synonym Full Names    potassium voltage-gated channel subfamily A member 4
 NCBI Official Symbol    KCNA4 [Similar Products]
 NCBI Official Synonym Symbols   
HK1; HBK4; PCN2; HPCN2; HUKII; KCNA8; KV1.4; KCNA4L
[Similar Products]
 NCBI Protein Information    potassium voltage-gated channel subfamily A member 4
 UniProt Protein Name    Potassium voltage-gated channel subfamily A member 4
 UniProt Synonym Protein Names   
HPCN2; Voltage-gated K(+) channel HuKII
 Protein Family    Potassium voltage-gated channel subfamily
 UniProt Gene Name    KCNA4 [Similar Products]
 UniProt Synonym Gene Names    KCNA4L [Similar Products]
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 NCBI Summary for KCNA4    Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential.[provided by RefSeq, Mar 2011]
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 UniProt Comments for KCNA4    Kv1.4: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11p14.1

Cellular Component: axon; integral component of membrane; integral component of plasma membrane; plasma membrane; voltage-gated potassium channel complex

Molecular Function: potassium ion binding; protein binding; voltage-gated potassium channel activity

Biological Process: potassium ion transmembrane transport; potassium ion transport; protein homooligomerization; regulation of ion transmembrane transport
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 Research Articles on KCNA4    1. Expression of Kv1.4 appears to increase in the spinal cord of mice modelling remitting-relapsing experimental allergic encephalomyelitis (rrEAE) in peak and remitting phases.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with KCNA4 elisa kitPathways associated with KCNA4 elisa kit
 Reference Product  PubMed Publications
 KCNA5 elisa kit  >25 publications with KCNA4 and KCNA5
 KCNA2 elisa kit  >22 publications with KCNA4 and KCNA2
 KCNAB1 elisa kit  >4 publications with KCNA4 and KCNAB1
 DLG1 elisa kit  >3 publications with KCNA4 and DLG1
 KCNH2 elisa kit  >2 publications with KCNA4 and KCNH2
 KCNH6 elisa kit  >1 publications with KCNA4 and KCNH6
 KCNAB2 elisa kit  >1 publications with KCNA4 and KCNAB2
 Products by Pathway  Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Voltage Gated Potassium Channels Pathway antibodies  Voltage Gated Potassium Channels Pathway Diagram
Diseases associated with KCNA4 elisa kitOrgans/Tissues associated with KCNA4 elisa kit
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >14 publications with KCNA4 and Cardiovascular Diseases
 Heart Diseases Antibodies  >14 publications with KCNA4 and Heart Diseases
 Brain Diseases Antibodies  >5 publications with KCNA4 and Brain Diseases
 Disease Models, Animal Antibodies  >5 publications with KCNA4 and Disease Models, Animal
 Pain Antibodies  >4 publications with KCNA4 and Pain
 Cardiomegaly Antibodies  >3 publications with KCNA4 and Cardiomegaly
 Myocardial Infarction Antibodies  >3 publications with KCNA4 and Myocardial Infarction
 Inflammation Antibodies  >3 publications with KCNA4 and Inflammation
 Fibrosis Antibodies  >2 publications with KCNA4 and Fibrosis
 Neurobehavioral Manifestations Antibodies  >2 publications with KCNA4 and Neurobehavioral Manifestations
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >41 publications with KCNA4 and Brain
 Lung Antibodies  >2 publications with KCNA4 and Lung
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