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KCNH2 elisa kit :: Human Potassium voltage gated channel subfamily H member 2 (KCNH2) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7221798
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $675 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Potassium voltage gated channel subfamily H member 2 (KCNH2), ELISA Kit

★Popular Item★
 Also Known As   

Human Potassium voltage gated channel subfamily H member 2 (KCNH2) ELISA Kit

 Product Gene Name   

KCNH2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    613688
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of KCNH2. No significant cross-reactivity or interference between KCNH2 and analogues was observed. NOTE: Limited by current skills and knowledge, it is impossible for us to complete the cross-reactivity detection between KCNH2 and all the analogues, therefore, cross reaction may still exist in some cases.
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 Samples    Serum, plasma, cell culture supernatants, body fluid and tissue homogenate
 Assay Type    Competitive
 Sensitivity    1.0 pg/mL.
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of KCNH2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for KCNH2 purchase    MBS7221798 is a ready-to-use microwell, strip plate Competitive ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Potassium voltage gated channel subfamily H member 2 (KCNH2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing KCNH2, with an estimated sensitivity of 1.0 pg/mL. The ELISA analytical biochemical technique of the MBS7221798 kit is based on KCNH2 antibody-KCNH2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect KCNH2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, KCNH2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, cell culture supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for KCNH2 elisa kit

   Intended Uses||This KCNH2 ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Human KCNH2. This ELISA kit for research use only, not for therapeutic or diagnostic applications!

Principle of the Assay: KCNH2 ELISA kit applies the competitive enzyme immunoassay technique utilizing a polyclonal anti-KCNH2 antibody and an KCNH2-HRP conjugate. The assay sample and buffer are incubated together with KCNH2-HRP conjugate in pre-coated plate for one hour. After the incubation period, the wells are decanted and washed five times. The wells are then incubated with a substrate for HRP enzyme. The product of the enzyme-substrate reaction forms a blue colored complex. Finally, a stop solution is added to stop the reaction, which will then turn the solution yellow. The intensity of color is measured spectrophotometrically at 450nm in a microplate reader. The intensity of the color is inversely proportional to the KCNH2 concentration since KCNH2 from samples and KCNH2-HRP conjugate compete for the anti-KCNH2 antibody binding site. Since the number of sites is limited, as more sites are occupied by KCNH2 from the sample, fewer sites are left to bind KCNH2-HRP conjugate. A standard curve is plotted relating the intensity of the color (O.D) to the concentration of standards. The KCNH2 concentration in each sample is interpolated from this standard curve.
 Product Categories/Family for KCNH2 elisa kit    Neurobiology
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 Typical Testing Data/Standard Curve (for reference only) of KCNH2 elisa kit    KCNH2 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS7221798. Click to request current manual
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NCBI/Uniprot data below describe general gene information for KCNH2. It may not necessarily be applicable to this product.
 NCBI GI #    7531135
 NCBI GeneID    3757
 NCBI Accession #    Q12809.1 [Other Products]
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 UniProt Secondary Accession #    O75418; O75680; Q708S9; Q9BT72; Q9BUT7; Q9H3P0; A5H1P7; C4PFH9; D3DX04 [Other Products]
 UniProt Related Accession #    Q12809 [Other Products]
 Molecular Weight    115,636 Da
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 NCBI Official Full Name    Potassium voltage-gated channel subfamily H member 2
 NCBI Official Synonym Full Names    potassium voltage-gated channel, subfamily H (eag-related), member 2
 NCBI Official Symbol    KCNH2 [Similar Products]
 NCBI Official Synonym Symbols   
ERG1; HERG; LQT2; SQT1; ERG-1; H-ERG; HERG1; Kv11.1
[Similar Products]
 NCBI Protein Information    potassium voltage-gated channel subfamily H member 2; eag homolog; eag-related protein 1; ether-a-go-go-related protein 1; ether-a-go-go-related gene potassium channel 1; voltage-gated potassium channel subunit Kv11.1; ether-a-go-go-related potassium channel protein
 UniProt Protein Name    Potassium voltage-gated channel subfamily H member 2
 UniProt Synonym Protein Names   
Eag homolog; Ether-a-go-go-related gene potassium channel 1; ERG-1; Eag-related protein 1; Ether-a-go-go-related protein 1; H-ERG; hERG-1; hERG1; Voltage-gated potassium channel subunit Kv11.1
 Protein Family    Potassium voltage-gated channel subfamily
 UniProt Gene Name    KCNH2 [Similar Products]
 UniProt Synonym Gene Names    ERG; ERG1; HERG; ERG-1; Eag-related protein 1; Ether-a-go-go-related protein 1; H-ERG; hERG-1; hERG1 [Similar Products]
 UniProt Entry Name    KCNH2_HUMAN
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 NCBI Summary for KCNH2    This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KCNH2    Kv11.1: the ether-a-go-go related gene is a pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel is associated with cardiac arrhythmias and rhythmic excitability of the pituitary. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with Kv11.2 and Kv11.3. Interacts with ALG10B. Heteromultimer with KCNE1 and KCNE2. Defects in Kv11.1 are the cause of long QT syndrome type 2 (LQT2), a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. Deafness is often associated with LQT2. Defects in Kv11.1 are the cause of short QT syndrome type 1 (SQT1), a heart disorder characterized by idiopathic persistently and uniformly short QT interval on ECG in the absence of structural heart disease in affected individuals. They cause syncope and sudden death. Four isoforms of the human protein are produced by alternative splicing. Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Membrane protein, multi-pass; Channel, potassium

Chromosomal Location of Human Ortholog: 7q36.1

Cellular Component: voltage-gated potassium channel complex; cell surface; cytoplasm; plasma membrane; nuclear envelope

Molecular Function: identical protein binding; voltage-gated potassium channel activity; protein binding; protein homodimerization activity; delayed rectifier potassium channel activity; ubiquitin protein ligase binding; inward rectifier potassium channel activity; two-component sensor activity

Biological Process: synaptic transmission; regulation of membrane potential; two-component signal transduction system (phosphorelay); potassium ion homeostasis; regulation of the rate of heart contraction by hormone; cardiac muscle contraction

Disease: Long Qt Syndrome 2; Short Qt Syndrome 1
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 Research Articles on KCNH2    1. hERG1 plays a role in the process of in vivo colorectal carcinogenesis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with KCNH2 elisa kitPathways associated with KCNH2 elisa kit
 Reference Product  PubMed Publications
 KCNQ1 elisa kit  >194 publications with KCNH2 and KCNQ1
 KCNE2 elisa kit  >78 publications with KCNH2 and KCNE2
 KCNA5 elisa kit  >4 publications with KCNH2 and KCNA5
 KCNA4 elisa kit  >2 publications with KCNH2 and KCNA4
 KCNQ2 elisa kit  >1 publications with KCNH2 and KCNQ2
 KCNA2 elisa kit  >1 publications with KCNH2 and KCNA2
 Products by Pathway  Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
 Voltage Gated Potassium Channels Pathway antibodies  Voltage Gated Potassium Channels Pathway Diagram
Diseases associated with KCNH2 elisa kitOrgans/Tissues associated with KCNH2 elisa kit
 Disease Name  Pubmed Publications
 Arrhythmias, Cardiac Antibodies  >299 publications with KCNH2 and Arrhythmias, Cardiac
 Heart Diseases Antibodies  >293 publications with KCNH2 and Heart Diseases
 Long QT Syndrome Antibodies  >279 publications with KCNH2 and Long QT Syndrome
 Tachycardia Antibodies  >68 publications with KCNH2 and Tachycardia
 Tachycardia, Ventricular Antibodies  >65 publications with KCNH2 and Tachycardia, Ventricular
 Syncope Antibodies  >64 publications with KCNH2 and Syncope
 Heart Arrest Antibodies  >58 publications with KCNH2 and Heart Arrest
 Torsades de Pointes Antibodies  >43 publications with KCNH2 and Torsades de Pointes
 Ventricular Fibrillation Antibodies  >38 publications with KCNH2 and Ventricular Fibrillation
 Atrial Fibrillation Antibodies  >27 publications with KCNH2 and Atrial Fibrillation
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >180 publications with KCNH2 and Heart
 Blood Antibodies  >30 publications with KCNH2 and Blood
 Kidney Antibodies  >12 publications with KCNH2 and Kidney
 Brain Antibodies  >11 publications with KCNH2 and Brain
 Ovary Antibodies  >10 publications with KCNH2 and Ovary
 Embryonic Tissue Antibodies  >10 publications with KCNH2 and Embryonic Tissue
 Lung Antibodies  >8 publications with KCNH2 and Lung
 Liver Antibodies  >3 publications with KCNH2 and Liver
 Pancreas Antibodies  >3 publications with KCNH2 and Pancreas
 Intestine Antibodies  >1 publications with KCNH2 and Intestine
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