AAA52612.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,213 Da
NCBI Official Full Name
pro-gastrin releasing peptide type 2, partial
NCBI Official Synonym Full Names
gastrin-releasing peptide
NCBI Protein Information
gastrin-releasing peptide; bombesin; prepro-GRP; neuromedin C; pre-progastrin releasing peptide
UniProt Protein Name
Gastrin-releasing peptide
UniProt Synonym Protein Names
GRP-10
UniProt Synonym Gene Names
UniProt Entry Name
GRP_HUMAN
NCBI Summary for PROGRP
This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for PROGRP
GRP: GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP- receptor gene expression, long-term potentiation, and amygdala- dependent memory for fear. Belongs to the bombesin/neuromedin-B/ranatensin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 18q21.1-q21.32
Cellular Component: extracellular space; extracellular region
Molecular Function: neuropeptide hormone activity; receptor binding
Biological Process: neuropeptide signaling pathway; signal transduction
Research Articles on PROGRP
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Products associated with PROGRP elisa kit
Pathways associated with PROGRP elisa kit
Diseases associated with PROGRP elisa kit
Organs/Tissues associated with PROGRP elisa kit
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