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PTGS1 elisa kit :: Human Prostaglandin Endoperoxide Synthase 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS733514
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells-(Competitive)  /  $455 +1 FREE 8GB USB
48-Strip-Wells-(Sandwich)  /  $455 +1 FREE 8GB USB
96-Strip-Wells-(Competitive)  /  $660 +1 FREE 8GB USB
96-Strip-Wells-(Sandwich)  /  $660 +1 FREE 8GB USB
5x96-Strip-Wells-(Competitive)  /  $2,925 +3 FREE 8GB USB
5x96-Strip-Wells-(Sandwich)  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells-(Competitive)  /  $5,490 +6 FREE 8GB USB
10x96-Strip-Wells-(Sandwich)  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Prostaglandin Endoperoxide Synthase 1 (PTGS1), ELISA Kit

★Popular Item★
 Also Known As   

Human Prostaglandin Endoperoxide Synthase 1 ELISA Kit

 Product Gene Name   

PTGS1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    176805
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 Species Reactivity    Human
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
 Assay Type    Competitive or Sandwich
 Detection Range    100-2500pg/mL
 Sensitivity    1.0pg/mL
 Intended Uses    This PTGS1 ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Human PTGS1. This ELISA kit for research use only, not for therapeutic or diagnostic applications!
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PTGS1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PTGS1 purchase    MBS733514 is a ready-to-use microwell, strip plate Competitive or Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Prostaglandin Endoperoxide Synthase 1 (PTGS1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 100-2500pg/mL in biological research samples containing PTGS1, with an estimated sensitivity of 1.0pg/mL. The ELISA analytical biochemical technique of the MBS733514 kit is based on PTGS1 antibody-PTGS1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PTGS1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PTGS1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for PTGS1 elisa kit

   Principle of the Assay: PTGS1 ELISA kit applies the quantitative sandwich enzyme immunoassay technique. The microtiter plate has been pre-coated with a monoclonal antibody specific for PTGS1. Standards or samples are then added to the microtiter plate wells and PTGS1 if present, will bind to the antibody pre-coated wells. In order to quantitatively determine the amount of PTGS1 present in the sample, a standardized preparation of horseradish peroxidase (HRP) -conjugated polyclonal antibody, specific for PTGS1 are added to each well to "sandwich" the PTGS1 immobilized on the plate. The microtiter plate undergoes incubation, and then the wells are thoroughly washed to remove all unbound components. Next, substrate solutions are added to each well. The enzyme (HRP) and substrate are allowed to react over a short incubation period. Only those wells that contain PTGS1 and enzyme-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm. A standard curve is plotted relating the intensity of the color (O.D.) to the concentration of standards. The PTGS1 concentration in each sample is interpolated from this standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of PTGS1 elisa kit    PTGS1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS733514. Click to request current manual
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NCBI/Uniprot data below describe general gene information for PTGS1. It may not necessarily be applicable to this product.
 NCBI GI #    17017287
 NCBI GeneID    5742
 NCBI Accession #    AAL33601.1 [Other Products]
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 UniProt Secondary Accession #    Q15122; Q3HY28; Q3HY29; Q5T7T6; Q5T7T7; Q5T7T8; A8K1V7; B4DHQ2; B4E2S5 [Other Products]
 UniProt Related Accession #    P23219 [Other Products]
 Molecular Weight    72,010 Da
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 NCBI Official Full Name    prostaglandin-endoperoxide synthase 1
 NCBI Official Synonym Full Names    prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
 NCBI Official Symbol    PTGS1 [Similar Products]
 NCBI Official Synonym Symbols   
COX1; COX3; PHS1; PCOX1; PES-1; PGHS1; PTGHS; PGG/HS; PGHS-1
[Similar Products]
 NCBI Protein Information    prostaglandin G/H synthase 1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1
 UniProt Protein Name    Prostaglandin G/H synthase 1
 UniProt Synonym Protein Names   
Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
 Protein Family    Prostaglandin G/H synthase
 UniProt Gene Name    PTGS1 [Similar Products]
 UniProt Synonym Gene Names    COX1; COX-1; PGH synthase 1; PGHS-1; PHS 1 [Similar Products]
 UniProt Entry Name    PGH1_HUMAN
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 NCBI Summary for PTGS1    This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
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 UniProt Comments for PTGS1    COX-1: May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells. Homodimer. Belongs to the prostaglandin G/H synthase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.99.1; Lipid Metabolism - arachidonic acid; Oxidoreductase

Chromosomal Location of Human Ortholog: 9q32-q33.3

Cellular Component: endoplasmic reticulum membrane; photoreceptor outer segment; intracellular membrane-bound organelle; cytoplasm; nucleus

Molecular Function: prostaglandin-endoperoxide synthase activity; peroxidase activity; dioxygenase activity; metal ion binding; heme binding

Biological Process: regulation of blood pressure; xenobiotic metabolic process; cyclooxygenase pathway; arachidonic acid metabolic process; response to oxidative stress; lipid metabolic process; prostaglandin biosynthetic process; inflammatory response; regulation of cell proliferation
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 Research Articles on PTGS1    1. Impacts of COX-1 gene polymorphisms on vascular outcomes in patients with ischemic stroke and treated with aspirin
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PTGS1 elisa kitPathways associated with PTGS1 elisa kit
 Reference Product  PubMed Publications
 ALOX5 elisa kit  >107 publications with PTGS1 and ALOX5
 PLA2G4A elisa kit  >92 publications with PTGS1 and PLA2G4A
 PTGES elisa kit  >14 publications with PTGS1 and PTGES
 PTGIS elisa kit  >8 publications with PTGS1 and PTGIS
 ALOX12 elisa kit  >6 publications with PTGS1 and ALOX12
 PTGES2 elisa kit  >5 publications with PTGS1 and PTGES2
 PTGES3 elisa kit  >4 publications with PTGS1 and PTGES3
 TBXAS1 elisa kit  >3 publications with PTGS1 and TBXAS1
 PLA2G2A elisa kit  >2 publications with PTGS1 and PLA2G2A
 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 C20 Prostanoid Biosynthesis Pathway antibodies  C20 Prostanoid Biosynthesis Pathway Diagram
 COX Reactions Pathway antibodies  COX Reactions Pathway Diagram
 Eicosanoid Synthesis Pathway antibodies  Eicosanoid Synthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
Diseases associated with PTGS1 elisa kitOrgans/Tissues associated with PTGS1 elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >978 publications with PTGS1 and Inflammation
 Cardiovascular Diseases Antibodies  >478 publications with PTGS1 and Cardiovascular Diseases
 Pain Antibodies  >343 publications with PTGS1 and Pain
 Necrosis Antibodies  >278 publications with PTGS1 and Necrosis
 Carcinoma Antibodies  >273 publications with PTGS1 and Carcinoma
 Edema Antibodies  >226 publications with PTGS1 and Edema
 Heart Diseases Antibodies  >156 publications with PTGS1 and Heart Diseases
 Hypertension Antibodies  >145 publications with PTGS1 and Hypertension
 Stomach Ulcer Antibodies  >140 publications with PTGS1 and Stomach Ulcer
 Adenocarcinoma Antibodies  >126 publications with PTGS1 and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1250 publications with PTGS1 and Blood
 Vascular Antibodies  >686 publications with PTGS1 and Vascular
 Brain Antibodies  >373 publications with PTGS1 and Brain
 Stomach Antibodies  >353 publications with PTGS1 and Stomach
 Muscle Antibodies  >345 publications with PTGS1 and Muscle
 Kidney Antibodies  >295 publications with PTGS1 and Kidney
 Heart Antibodies  >251 publications with PTGS1 and Heart
 Intestine Antibodies  >219 publications with PTGS1 and Intestine
 Lung Antibodies  >213 publications with PTGS1 and Lung
 Liver Antibodies  >193 publications with PTGS1 and Liver
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