AAH07713.2
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
96,261 Da
NCBI Official Full Name
PTPRN protein, partial
NCBI Official Synonym Full Names
protein tyrosine phosphatase, receptor type, N
NCBI Official Synonym Symbols
IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP [Similar Products]
NCBI Protein Information
receptor-type tyrosine-protein phosphatase-like N; ICA 512; PTP IA-2; islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N
UniProt Protein Name
Receptor-type tyrosine-protein phosphatase-like N
UniProt Synonym Protein Names
Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2
UniProt Synonym Gene Names
UniProt Entry Name
PTPRN_HUMAN
NCBI Summary for PTPRN
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
UniProt Comments for PTPRN
PTPRN: Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2. Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Receptor protein phosphatase, tyrosine
Chromosomal Location of Human Ortholog: 2q35-q36.1
Cellular Component: integral to membrane
Molecular Function: protein binding; GTPase binding; spectrin binding; protein tyrosine phosphatase activity
Biological Process: response to reactive oxygen species; response to cAMP; response to estrogen stimulus; insulin secretion; cytokine and chemokine mediated signaling pathway; response to glucose stimulus; protein amino acid dephosphorylation; response to insulin stimulus
Research Articles on PTPRN
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Products associated with PTPRN elisa kit
Pathways associated with PTPRN elisa kit
Diseases associated with PTPRN elisa kit
Organs/Tissues associated with PTPRN elisa kit
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