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PDI elisa kit :: Human Protein disulfide-isomerase precursor, PDI ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9300545 PDI elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Protein disulfide-isomerase precursor, PDI, ELISA Kit

★Popular Item★
 Also Known As   

Human Protein disulfide-isomerase precursor, PDI ELISA Kit

 Product Gene Name   

PDI elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 17; NC_000017.10 (79801034..79818544, complement). Location: 17q25
 OMIM    176790
 3D Structure    ModBase 3D Structure for P07237
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 Species Reactivity    Human
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non- biological sources of substances.
 Assay Type    Sandwich
 Detection Range    0.625 ng/ml - 20 ng/ml.
 Sensitivity    0.1 ng/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PDI elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PDI purchase    MBS9300545 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Protein disulfide-isomerase precursor, PDI, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.625 ng/ml - 20 ng/ml in biological research samples containing PDI, with an estimated sensitivity of 0.1 ng/ml. The ELISA analytical biochemical technique of the MBS9300545 kit is based on PDI antibody-PDI antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PDI antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PDI. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non- biological sources of substances. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for PDI elisa kit

   Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of PDI (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non- biological sources of substances.
Sample Manual Insert of MBS9300545. Click to request current manual
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NCBI/Uniprot data below describe general gene information for PDI. It may not necessarily be applicable to this product.
 NCBI GI #    20070125
 NCBI GeneID    5034
 NCBI Accession #    NP_000909.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000918.3 [Other Products]
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 UniProt Primary Accession #    P07237 [Other Products]
 UniProt Secondary Accession #    P30037; P32079; Q15205; Q6LDE5; B2RDQ2 [Other Products]
 UniProt Related Accession #    P07237 [Other Products]
 Molecular Weight    57,116 Da
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 NCBI Official Full Name    protein disulfide-isomerase
 NCBI Official Synonym Full Names    prolyl 4-hydroxylase, beta polypeptide
 NCBI Official Symbol    P4HB [Similar Products]
 NCBI Official Synonym Symbols   
DSI; GIT; PDI; PHDB; PDIA1; PO4DB; PO4HB; PROHB; ERBA2L; P4Hbeta
[Similar Products]
 NCBI Protein Information    protein disulfide-isomerase; p55; protocollagen hydroxylase; prolyl 4-hydroxylase subunit beta; collagen prolyl 4-hydroxylase beta; thyroid hormone-binding protein p55; glutathione-insulin transhydrogenase; cellular thyroid hormone-binding protein; protein disulfide isomerase-associated 1; protein disulfide isomerase/oxidoreductase; protein disulfide isomerase family A, member 1; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide
 UniProt Protein Name    Protein disulfide-isomerase
 UniProt Synonym Protein Names   
Cellular thyroid hormone-binding protein; Prolyl 4-hydroxylase subunit beta; p55
 UniProt Gene Name    P4HB [Similar Products]
 UniProt Synonym Gene Names    ERBA2L; PDI; PDIA1; PO4DB; PDI [Similar Products]
 UniProt Entry Name    PDIA1_HUMAN
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 NCBI Summary for PDI    This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PDI    PDIA1: This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Homodimer. Monomers and homotetramers may also occur. Also constitutes the structural subunit of prolyl 4-hydroxylase and of the microsomal triacylglycerol transfer protein MTTP in mammalian cells. Stabilizes both enzymes and retain them in the ER without contributing to the catalytic activity. Binds UBQLN1. Binds to CD4, and upon HIV-1 binding to the cell membrane, is part of a P4HB/PDI-CD4-CXCR4-gp120 complex. Belongs to the protein disulfide isomerase family.

Protein type: EC 5.3.4.1; Isomerase; Endoplasmic reticulum; Nuclear receptor co-regulator; Oxidoreductase

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: focal adhesion; endoplasmic reticulum lumen; endoplasmic reticulum; extracellular region; melanosome; plasma membrane; ER-Golgi intermediate compartment

Molecular Function: protein binding; enzyme binding; procollagen-proline 4-dioxygenase activity; protein heterodimerization activity; endopeptidase activity; protein disulfide isomerase activity

Biological Process: extracellular matrix organization and biogenesis; response to reactive oxygen species; protein folding; cell redox homeostasis; lipoprotein metabolic process; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; proteolysis

Disease: Cole-carpenter Syndrome 1
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 Research Articles on PDI    1. A mixed disulfide complex was formed with the catalytic domain A1 from human PDI consistent with a model for cotranslational oxidative protein folding wherein PDI acts as a placeholder that is relieved by the pairing of cysteines caused by substrate folding.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PDI elisa kitPathways associated with PDI elisa kit
 Reference Product  PubMed Publications
 LEPRE1 elisa kit  >1 publications with PDI and LEPRE1
 COL1A1 elisa kit  >1 publications with PDI and COL1A1
 P4HA3 elisa kit  >1 publications with PDI and P4HA3
 LEPREL1 elisa kit  >1 publications with PDI and LEPREL1
 ERO1L elisa kit  >1 publications with PDI and ERO1L
 Products by Pathway  Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
Diseases associated with PDI elisa kitOrgans/Tissues associated with PDI elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >6 publications with PDI and Neoplasms
 Inflammation Antibodies  >5 publications with PDI and Inflammation
 Nervous System Diseases Antibodies  >3 publications with PDI and Nervous System Diseases
 Necrosis Antibodies  >3 publications with PDI and Necrosis
 Fibrosis Antibodies  >2 publications with PDI and Fibrosis
 Cardiovascular Diseases Antibodies  >2 publications with PDI and Cardiovascular Diseases
 Immune System Diseases Antibodies  >2 publications with PDI and Immune System Diseases
 Weight Loss Antibodies  >1 publications with PDI and Weight Loss
 Breast Neoplasms Antibodies  >1 publications with PDI and Breast Neoplasms
 Heart Diseases Antibodies  >1 publications with PDI and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >18 publications with PDI and Vascular
 Heart Antibodies  >13 publications with PDI and Heart
 Blood Antibodies  >13 publications with PDI and Blood
 Muscle Antibodies  >8 publications with PDI and Muscle
 Embryonic Tissue Antibodies  >7 publications with PDI and Embryonic Tissue
 Bone Antibodies  >6 publications with PDI and Bone
 Bone Marrow Antibodies  >5 publications with PDI and Bone Marrow
 Connective Tissue Antibodies  >4 publications with PDI and Connective Tissue
 Umbilical Cord Antibodies  >3 publications with PDI and Umbilical Cord
 Nerve Antibodies  >2 publications with PDI and Nerve
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