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LOX elisa kit :: Human Protein-lysine 6-oxidase ELISA Kit

Scan QR to view Datasheet Catalog #    MBS280253 LOX elisa kit
Unit / Price
48-Strip-Wells  /  $465 +1 FREE 8GB USB
96-Strip-Wells  /  $790 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,500 +4 FREE 8GB USB
10x96-Strip-Wells  /  $6,655 +8 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Protein-lysine 6-oxidase (LOX), ELISA Kit

★Popular Item★
 Also Known As   

Human Protein-lysine 6-oxidase (LOX) ELISA Kit

 Product Gene Name   

LOX elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    S78694 mRNA
 3D Structure    ModBase 3D Structure for P28300
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Human LOX. No significant cross-reactivity or interference between Human LOX and analogues was observed.
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 Samples    Serum, Plasma, Other biological fluids
 Assay Type    Sandwich
 Sample Volume    1-200 uL
 Precision    Intra-assay Precision (Precision within an assay)
Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Inter-assay Precision (Precision between assays)
Three samples of known concentration were tested in forty separate assays to assess inter-assay precision.
CV (%) = SD/meanX100
Intra-Assay: CV
Inter-Assay: CV
 Detection Wavelength    450 nm
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 Preparation and Storage    Store at 2-8 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of LOX elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for LOX purchase    MBS280253 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Protein-lysine 6-oxidase (LOX) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing LOX. The ELISA analytical biochemical technique of the MBS280253 kit is based on LOX antibody-LOX antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect LOX antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, LOX. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Other biological fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for LOX elisa kit

   Principle of the Assay: This assay employs a two-site sandwich ELISA to quantitate LOX in samples. An antibody specific for LOX has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyLOX present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for LOX is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of LOX bound in the initial step. The color development is stopped and the intensity of the color is measured.
Sample Manual Insert of MBS280253. Click to request current manual
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NCBI/Uniprot data below describe general gene information for LOX. It may not necessarily be applicable to this product.
 NCBI GI #    20149540
 NCBI GeneID    4015
 NCBI Accession #    NP_002308.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002317.6 [Other Products]
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 UniProt Primary Accession #    P28300 [Other Products]
 UniProt Secondary Accession #    Q5FWF0; B2R5Q3 [Other Products]
 UniProt Related Accession #    P28300 [Other Products]
 Molecular Weight    46,944 Da
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 NCBI Official Full Name    protein-lysine 6-oxidase isoform 1 preproprotein
 NCBI Official Synonym Full Names    lysyl oxidase
 NCBI Official Symbol    LOX [Similar Products]
 NCBI Official Synonym Symbols   
AAT10
[Similar Products]
 NCBI Protein Information    protein-lysine 6-oxidase
 UniProt Protein Name    Protein-lysine 6-oxidase
 UniProt Synonym Protein Names   
Lysyl oxidase
 Protein Family    Protein-lysine 6-oxidase
 UniProt Gene Name    LOX [Similar Products]
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 NCBI Summary for LOX    This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016]
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 UniProt Comments for LOX    LOX: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression. Belongs to the lysyl oxidase family.

Protein type: EC 1.4.3.13; Oxidoreductase; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q23.1

Cellular Component: collagen; extracellular region; extracellular space; nucleus; proteinaceous extracellular matrix

Molecular Function: copper ion binding; protein binding; protein-lysine 6-oxidase activity

Biological Process: blood vessel morphogenesis; cellular protein modification process; collagen fibril organization; elastic fiber assembly; extracellular matrix organization; heart development; lung development; response to drug; response to steroid hormone; wound healing

Disease: Aortic Aneurysm, Familial Thoracic 10
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 Research Articles on LOX    1. Our findings suggest that LOX has a role in cancer cell mitosis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LOX elisa kitPathways associated with LOX elisa kit
 Reference Product  PubMed Publications
 LOXL1 elisa kit  >63 publications with LOX and LOXL1
 SRC elisa kit  >37 publications with LOX and SRC
 FGF2 elisa kit  >15 publications with LOX and FGF2
 BMP1 elisa kit  >8 publications with LOX and BMP1
 FBLN5 elisa kit  >8 publications with LOX and FBLN5
 SNAI1 elisa kit  >2 publications with LOX and SNAI1
 EFEMP2 elisa kit  >2 publications with LOX and EFEMP2
 Products by Pathway  Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Crosslinking Of Collagen Fibrils Pathway antibodies  Crosslinking Of Collagen Fibrils Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
Diseases associated with LOX elisa kitOrgans/Tissues associated with LOX elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >672 publications with LOX and Inflammation
 Cardiovascular Diseases Antibodies  >628 publications with LOX and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >424 publications with LOX and Disease Models, Animal
 Necrosis Antibodies  >255 publications with LOX and Necrosis
 Heart Diseases Antibodies  >194 publications with LOX and Heart Diseases
 Lung Diseases Antibodies  >179 publications with LOX and Lung Diseases
 Neoplasms, Experimental Antibodies  >158 publications with LOX and Neoplasms, Experimental
 Hypertension Antibodies  >155 publications with LOX and Hypertension
 Fibrosis Antibodies  >155 publications with LOX and Fibrosis
 Lung Neoplasms Antibodies  >132 publications with LOX and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >780 publications with LOX and Vascular
 Muscle Antibodies  >426 publications with LOX and Muscle
 Brain Antibodies  >398 publications with LOX and Brain
 Lung Antibodies  >305 publications with LOX and Lung
 Heart Antibodies  >290 publications with LOX and Heart
 Liver Antibodies  >263 publications with LOX and Liver
 Bone Antibodies  >250 publications with LOX and Bone
 Skin Antibodies  >187 publications with LOX and Skin
 Kidney Antibodies  >175 publications with LOX and Kidney
 Embryonic Tissue Antibodies  >164 publications with LOX and Embryonic Tissue
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