NP_001273989.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
79,371 Da
NCBI Official Full Name
rab5 GDP/GTP exchange factor isoform a
NCBI Official Synonym Full Names
RAB guanine nucleotide exchange factor (GEF) 1
NCBI Protein Information
rab5 GDP/GTP exchange factor; rabaptin-5-associated exchange factor for Rab5
UniProt Protein Name
Rab5 GDP/GTP exchange factor
UniProt Synonym Protein Names
RAP1; Rabaptin-5-associated exchange factor for Rab5; Rabex-5
UniProt Synonym Gene Names
UniProt Entry Name
RABX5_HUMAN
NCBI Summary for RABGEF1
RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]).[supplied by OMIM, Mar 2010]
UniProt Comments for RABGEF1
RABGEF1: Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase. Interacts with RGS14; the interaction is GTP-dependent. Heterodimer with RABEP1. The heterodimer binds RAB4A and RAB5A that have been activated by GTP-binding. Interacts with RAB21, and with 100-fold lower affinity also with RAB22. Binds TSC2, GGA1, GGA2, GGA3, AP1G1 and AP1G2. Interacts with ubiquitinated EGFR. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; GAPs, Rab
Chromosomal Location of Human Ortholog: 7q11.21
Cellular Component: recycling endosome; early endosome; vesicle
Molecular Function: protein binding; DNA binding; zinc ion binding; ubiquitin-protein ligase activity; Rab guanyl-nucleotide exchange factor activity; Rab GTPase binding
Biological Process: negative regulation of protein amino acid phosphorylation; negative regulation of mast cell degranulation; negative regulation of inflammatory response; protein ubiquitination; negative regulation of Ras protein signal transduction; negative regulation of receptor-mediated endocytosis; endocytosis; protein targeting to membrane; negative regulation of leukocyte migration
Research Articles on RABGEF1
Precautions
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Products associated with RABGEF1 elisa kit
Diseases associated with RABGEF1 elisa kit
Organs/Tissues associated with RABGEF1 elisa kit
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