CAG38796.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,966 Da
NCBI Official Full Name
RAD51
NCBI Official Synonym Full Names
RAD51 recombinase
NCBI Official Synonym Symbols
RECA; BRCC5; MRMV2; HRAD51; RAD51A; HsRad51; HsT16930 [Similar Products]
NCBI Protein Information
DNA repair protein RAD51 homolog 1; RAD51 homolog A; RecA-like protein; recombination protein A; RecA, E. coli, homolog of; BRCA1/BRCA2-containing complex, subunit 5
UniProt Protein Name
DNA repair protein RAD51 homolog 1
UniProt Synonym Protein Names
RAD51 homolog A
UniProt Synonym Gene Names
UniProt Entry Name
RAD51_HUMAN
NCBI Summary for RAD51
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
UniProt Comments for RAD51
RAD51: a member of the RAD51 protein family. Involved in the homologous recombination and repair of DNA. Interacts with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. Interacts with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both its intracellular localization and DNA-binding ability. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Defects in RAD51 are associated with breast cancer. Two alternatively spliced isoforms have been reported.
Protein type: Mitochondrial; DNA repair, damage
Chromosomal Location of Human Ortholog: 15q15.1
Cellular Component: nuclear chromosome; PML body; condensed nuclear chromosome; mitochondrion; condensed chromosome; nucleoplasm; lateral element; mitochondrial matrix; perinuclear region of cytoplasm; cytoplasm; nucleolus; microtubule organizing center; nucleus
Molecular Function: protein C-terminus binding; identical protein binding; protein binding; double-stranded DNA binding; damaged DNA binding; single-stranded DNA binding; ATP binding; single-stranded DNA-dependent ATPase activity
Biological Process: DNA unwinding during replication; meiosis; DNA recombinase assembly; mitotic recombination; meiotic recombination; double-strand break repair; positive regulation of DNA ligation; DNA repair; response to DNA damage stimulus; protein homooligomerization; double-strand break repair via homologous recombination; DNA recombination
Disease: Breast Cancer; Mirror Movements 2
Research Articles on RAD51
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Products associated with RAD51 elisa kit
Pathways associated with RAD51 elisa kit
Diseases associated with RAD51 elisa kit
Organs/Tissues associated with RAD51 elisa kit
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