NP_001136043.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,049 Da
NCBI Official Full Name
DNA repair protein RAD51 homolog 4 isoform 6
NCBI Official Synonym Full Names
RAD51 paralog D
NCBI Protein Information
DNA repair protein RAD51 homolog 4; RAD51 homolog D; RAD51-like protein 3; recombination repair protein
UniProt Protein Name
DNA repair protein RAD51 homolog 4
UniProt Synonym Protein Names
R51H3; RAD51 homolog D; RAD51-like protein 3; TRAD
UniProt Synonym Gene Names
UniProt Entry Name
RA51D_HUMAN
NCBI Summary for RAD51L3
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream ring finger and FYVE-like domain containing 1 (RFFL) gene. [provided by RefSeq, Jan 2011]
UniProt Comments for RAD51L3
RAD51L3: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Defects in RAD51D are a cause of susceptibility to familial breast-ovarian cancer type 4 (BROVCA4). A condition associated with familial predisposition to cancer of the breast and ovaries. Characteristic features in affected families are an early age of onset of breast cancer (often before age 50), increased chance of bilateral cancers (cancer that develop in both breasts, or both ovaries, independently), frequent occurrence of breast cancer among men, increased incidence of tumors of other specific organs, such as the prostate. Belongs to the RecA family. RAD51 subfamily. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 17q11
Cellular Component: centrosome; chromosome, telomeric region; cytoplasm; replication fork; nucleus
Molecular Function: DNA-dependent ATPase activity; gamma-tubulin binding; protein binding; DNA binding; four-way junction DNA binding; ATP binding; single-stranded DNA binding
Biological Process: meiotic recombination; strand invasion; DNA repair; telomere maintenance; double-strand break repair via homologous recombination
Disease: Breast-ovarian Cancer, Familial, Susceptibility To, 4
Research Articles on RAD51L3
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Products associated with RAD51L3 elisa kit
Pathways associated with RAD51L3 elisa kit
Diseases associated with RAD51L3 elisa kit
Organs/Tissues associated with RAD51L3 elisa kit
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