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RORC elisa kit :: Human RAR-related orphan receptor C ELISA Kit

Scan QR to view Datasheet Catalog #    MBS911044
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RAR-related orphan receptor C (RORC), ELISA Kit

★Popular Item★
 Also Known As   

Human Nuclear receptor ROR-gamma, RORC ELISA Kit

 Product Synonym Names    Human Nuclear receptor ROR-gamma (RORC) ELISA kit; MGC129539; NR1F3; RORG; RZR-GAMMA; RZRG; TOR; RAR-related orphan receptor C; isoform a; RAR-related orphan receptor gamma; nuclear receptor ROR-gamma; retinoic acid-binding receptor gamma; retinoid-rela; RAR-related orphan receptor C
 Product Gene Name   

RORC elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS911044 Testing Data    Testing Data PDF
 OMIM    602943
 3D Structure    ModBase 3D Structure for P51449
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of human RORC. No significant cross-reactivity or interference between human RORC and analogues was observed.
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 Samples    Serum, plasma, tissue homogenates, cell lysates.
 Assay Type    Sandwich
 Detection Range    12.5 pg/ml -800 pg/ml.
 Sensitivity    3.12 pg/ml.
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.
 Inter-assay Precision    Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of RORC elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for RORC purchase    MBS911044 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the RAR-related orphan receptor C (RORC) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 12.5 pg/ml -800 pg/ml in biological research samples containing RORC, with an estimated sensitivity of 3.12 pg/ml. The ELISA analytical biochemical technique of the MBS911044 kit is based on RORC antibody-RORC antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect RORC antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, RORC. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates, cell lysates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for RORC elisa kit

   Principle of the Assay||This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for RORC has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any RORC present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for RORC is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of RORC bound in the initial step. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of RORC elisa kit    RORC elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS911044. Click to request current manual
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NCBI/Uniprot data below describe general gene information for RORC. It may not necessarily be applicable to this product.
 NCBI GI #    48255918
 NCBI GeneID    6097
 NCBI Accession #    NP_001001523.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001001523.1 [Other Products]
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 UniProt Primary Accession #    P51449 [Other Products]
 UniProt Secondary Accession #    Q5SZR9; Q8N5V7; Q8NCY8 [Other Products]
 UniProt Related Accession #    P51449 [Other Products]
 Molecular Weight    58,195 Da
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 NCBI Official Full Name    nuclear receptor ROR-gamma isoform b
 NCBI Official Synonym Full Names    RAR-related orphan receptor C
 NCBI Official Symbol    RORC [Similar Products]
 NCBI Official Synonym Symbols   
TOR; RORG; RZRG; NR1F3; RZR-GAMMA
[Similar Products]
 NCBI Protein Information    nuclear receptor ROR-gamma; nuclear receptor RZR-gamma; retinoic acid-binding receptor gamma; retinoid-related orphan receptor gamma; RAR-related orphan receptor C, isoform a; RAR-related orphan nuclear receptor variant 2; nuclear receptor subfamily 1 group F member 3
 UniProt Protein Name    Nuclear receptor ROR-gamma
 UniProt Synonym Protein Names   
Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; RAR-related orphan receptor C; Retinoid-related orphan receptor-gamma
 Protein Family    Nuclear receptor
 UniProt Gene Name    RORC [Similar Products]
 UniProt Synonym Gene Names    NR1F3; RORG; RZRG [Similar Products]
 UniProt Entry Name    RORG_HUMAN
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 NCBI Summary for RORC    The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RORC    RORC: Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor; Nuclear receptor

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein binding; ligand-dependent nuclear receptor activity; DNA binding; zinc ion binding; sequence-specific DNA binding; oxysterol binding; steroid hormone receptor activity; transcription factor activity

Biological Process: Peyer's patch development; transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; T-helper cell differentiation; regulation of fat cell differentiation; positive regulation of transcription, DNA-dependent; T cell differentiation in the thymus; positive regulation of circadian rhythm; regulation of gamma-delta T cell differentiation; lymph node development; protein amino acid phosphorylation; xenobiotic metabolic process; regulation of steroid metabolic process; gene expression; steroid hormone mediated signaling; circadian regulation of gene expression
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 Research Articles on RORC    1. In Th17 cells, RORC repressed EP2 by directly silencing PTGER2 transcription, and knock down of RORC restored EP2 expression in Th17 cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with RORC elisa kitPathways associated with RORC elisa kit
 Reference Product  PubMed Publications
 RORA elisa kit  >18 publications with RORC and RORA
 RORB elisa kit  >5 publications with RORC and RORB
 NR1D1 elisa kit  >5 publications with RORC and NR1D1
 NR1D2 elisa kit  >2 publications with RORC and NR1D2
 RXRA elisa kit  >1 publications with RORC and RXRA
 Products by Pathway  Pathway Diagram
 Circadian Rhythm Pathway antibodies  Circadian Rhythm Pathway Diagram
 Circadian Rhythm Pathway antibodies  Circadian Rhythm Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
Diseases associated with RORC elisa kitOrgans/Tissues associated with RORC elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >116 publications with RORC and Inflammation
 Disease Models, Animal Antibodies  >41 publications with RORC and Disease Models, Animal
 Nervous System Diseases Antibodies  >37 publications with RORC and Nervous System Diseases
 Brain Diseases Antibodies  >25 publications with RORC and Brain Diseases
 Necrosis Antibodies  >23 publications with RORC and Necrosis
 Cardiovascular Diseases Antibodies  >18 publications with RORC and Cardiovascular Diseases
 Liver Diseases Antibodies  >9 publications with RORC and Liver Diseases
 Atherosclerosis Antibodies  >7 publications with RORC and Atherosclerosis
 Kidney Diseases Antibodies  >5 publications with RORC and Kidney Diseases
 Liver Neoplasms Antibodies  >3 publications with RORC and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >5 publications with RORC and Kidney
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