NP_001041670.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
62,614 Da
NCBI Official Full Name
meiotic recombination protein REC8 homolog
NCBI Official Synonym Full Names
REC8 meiotic recombination protein
NCBI Protein Information
meiotic recombination protein REC8 homolog; REC8-like 1; cohesin Rec8p; kleisin-alpha; cohesion rec8p; human homolog of rad21, S. pombe; meiotic recombination protein REC8-like 1; recombination and sister chromatid cohesion protein homolog; meiotic recombination and sister chromatid cohesion phosphoprotein of the rad21p family
UniProt Protein Name
Meiotic recombination protein REC8 homolog
UniProt Synonym Protein Names
Cohesin Rec8p
UniProt Synonym Gene Names
UniProt Entry Name
REC8_HUMAN
NCBI Summary for REC8
This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for REC8
REC8: Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II. Belongs to the rad21 family. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 14q11.2-q12
Cellular Component: male germ cell nucleus; lateral element; nucleus
Biological Process: meiosis; fertilization; linear element formation; male meiosis I; meiotic recombination; sister chromatid cohesion; spermatogenesis; oocyte maturation; spermatid development; double-strand break repair via homologous recombination
Research Articles on REC8
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Pathways associated with REC8 elisa kit
Diseases associated with REC8 elisa kit
Organs/Tissues associated with REC8 elisa kit
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