AAH05956.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
13,011 Da
NCBI Official Full Name
Relaxin 1
NCBI Official Synonym Full Names
relaxin 1
NCBI Official Synonym Symbols
H1; H1RLX; RLXH1; bA12D24.3.1; bA12D24.3.2 [Similar Products]
NCBI Protein Information
prorelaxin H1; preprorelaxin H1
UniProt Protein Name
Prorelaxin H1
UniProt Entry Name
REL1_HUMAN
NCBI Summary for RLN1
Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The protein encoded by this gene is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. [provided by RefSeq, Jan 2013]
UniProt Comments for RLN1
RLN1: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix. Belongs to the insulin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 9p24.1
Cellular Component: extracellular region
Molecular Function: hormone activity
Biological Process: female pregnancy; signal transduction
Research Articles on RLN1
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Organs/Tissues associated with RLN1 elisa kit
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