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RNLS elisa kit :: Human RNLS (Renalase) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2540308 RNLS elisa kit
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RNLS (Renalase), ELISA Kit

 Also Known As   

Human RNLS (Renalase) ELISA Kit

 Product Gene Name   

RNLS elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    609360
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 Species Reactivity    Human
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 Specificity    This kit recognizes natural and recombinantHumanRNLS. No significant cross-reactivity or interference between HumanRNLS and analogues was observed.
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 Samples    Serum, plasma and other biological fluids
 Assay Type    Quantitative Sandwich
 Detection Range    7.813-500ng/mL
 Sensitivity    4.688ng/mL
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 Preparation and Storage    Store at 4 degree C.
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of RNLS elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for RNLS purchase    MBS2540308 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the RNLS (Renalase) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 7.813-500ng/mL in biological research samples containing RNLS, with an estimated sensitivity of 4.688ng/mL. The ELISA analytical biochemical technique of the MBS2540308 kit is based on RNLS antibody-RNLS antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect RNLS antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, RNLS. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma and other biological fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for RNLS elisa kit

   Intended Uses: This ELISA kit applies to the invitro quantitative determination of HumanRNLSconcentrations in serum, plasma and other biological fluids.

Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to RNLS. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for RNLSand Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain RNLS, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of RNLS.You can calculate the concentration of RNLSin the samples by comparing the OD of the samples to the standard curve.
Sample Manual Insert of MBS2540308. Click to request current manual
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NCBI/Uniprot data below describe general gene information for RNLS. It may not necessarily be applicable to this product.
 NCBI GI #    237649117
 NCBI GeneID    55328
 NCBI Accession #    NP_001026879.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001031709.2 [Other Products]
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 UniProt Secondary Accession #    Q9BS33; Q9NUP8 [Other Products]
 UniProt Related Accession #    Q5VYX0 [Other Products]
 Molecular Weight    34,949 Da
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 NCBI Official Full Name    renalase isoform 1
 NCBI Official Synonym Full Names    renalase, FAD dependent amine oxidase
 NCBI Official Symbol    RNLS [Similar Products]
 NCBI Official Synonym Symbols   
C10orf59; RENALASE
[Similar Products]
 NCBI Protein Information    renalase
 UniProt Protein Name    Renalase
 UniProt Synonym Protein Names   
Monoamine oxidase-C; MAO-C
 UniProt Gene Name    RNLS [Similar Products]
 UniProt Synonym Gene Names    C10orf59; MAO-C [Similar Products]
 UniProt Entry Name    RNLS_HUMAN
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 NCBI Summary for RNLS    Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney (Xu et al., 2005 [PubMed 15841207]).[supplied by OMIM, Mar 2008]
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 UniProt Comments for RNLS    RENALASE: Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. According to PubMed:17385068, is unlikely that renalase has physiologically relevant catecholamine-oxidizing activity. Belongs to the renalase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Oxidoreductase; EC 1.6.3.5; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10q23.31
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 Research Articles on RNLS    1. marked increase of glomerular renalase and its association with macrophages suggest that it might play an important role in disease progression of LN
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with RNLS elisa kitOrgans/Tissues associated with RNLS elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >3 publications with RNLS and Inflammation
 Cardiovascular Diseases Antibodies  >2 publications with RNLS and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >2 publications with RNLS and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >2 publications with RNLS and Neoplasm Metastasis
 Hypertension Antibodies  >2 publications with RNLS and Hypertension
 Heart Diseases Antibodies  >1 publications with RNLS and Heart Diseases
 Memory Disorders Antibodies  >1 publications with RNLS and Memory Disorders
 Learning Disorders Antibodies  >1 publications with RNLS and Learning Disorders
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >2 publications with RNLS and Muscle
 Eye Antibodies  >2 publications with RNLS and Eye
 Kidney Antibodies  >2 publications with RNLS and Kidney
 Brain Antibodies  >2 publications with RNLS and Brain
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