NP_067722.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
100,257 Da
NCBI Official Full Name
rap guanine nucleotide exchange factor 3
NCBI Official Synonym Full Names
Rap guanine nucleotide exchange factor 3
NCBI Official Synonym Symbols
NCBI Protein Information
rap guanine nucleotide exchange factor 3
UniProt Protein Name
Rap guanine nucleotide exchange factor 3
UniProt Synonym Protein Names
Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; EPAC 1; cAMP-regulated guanine nucleotide exchange factor I; cAMP-GEFI
UniProt Synonym Gene Names
UniProt Entry Name
RPGF3_RAT
NCBI Summary for RAPGEF3
binds cAMP and activates the Ras superfamily guanine nucleotide binding protein (Rap1A)in a PKA-independent manner [RGD, Feb 2006]
UniProt Comments for RAPGEF3
Epac1: Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GEFs, misc.; GEFs
Cellular Component: apical part of cell; basal plasma membrane; brush border membrane; cell soma; cortical actin cytoskeleton; filopodium; growth cone; lamellipodium; microvillus; nerve terminal; perinuclear region of cytoplasm; plasma membrane
Molecular Function: cAMP binding; guanyl-nucleotide exchange factor activity; protein binding; protein domain specific binding; Rap guanyl-nucleotide exchange factor activity
Biological Process: brain development; negative regulation of collagen biosynthetic process; positive regulation of angiogenesis; positive regulation of cell size; positive regulation of GTPase activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of protein export from nucleus; positive regulation of smooth muscle cell migration; positive regulation of stress fiber formation; positive regulation of syncytium formation by plasma membrane fusion; positive regulation of transcription from RNA polymerase II promoter; Rap protein signal transduction; response to nicotine; spinal cord development
Research Articles on RAPGEF3
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Products associated with RAPGEF3 elisa kit
Pathways associated with RAPGEF3 elisa kit
Diseases associated with RAPGEF3 elisa kit
Organs/Tissues associated with RAPGEF3 elisa kit
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