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RNLS elisa kit :: Human Renalase (RNLS) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2020965 (SPECIAL PROMOTION: Get FREE Starbucks gift card ($5 for 48-Wells-Kit or $10 for 96-Wells-Kit. Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells  /  $270 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $665 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,715 +3 FREE 8GB USB
10x96-Strip-Wells  /  $4,895 +6 FREE 8GB USB
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 Product Name   

Renalase (RNLS), ELISA Kit

★Popular Item★
 Also Known As   

Renalase (RNLS) ELISA Kit

 Product Synonym Names    MAO-C; C10orf59; FAD-Dependent Amine Oxidase; Monoamine oxidase-C; alpha-NAD(P)H oxidase/anomerase
 Product Gene Name   

RNLS elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    609360
 3D Structure    ModBase 3D Structure for Q5VYX0
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Renalase (RNLS).
No significant cross-reactivity or interference between Renalase (RNLS) and analogues was observed.
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 Assay Type    Double-antibody Sandwich
 Samples    Serum, Plasma, Tissue homogenates, Cell lysates, Cell culture supernates and Other Biological Fluids
 Detection Range    3.12-200ng/mL
 Sensitivity    < 1.37ng/mL
 Application    Enzyme-linked immunosorbent assay for Antigen Detection.
 Intra-assay Precision (Precision within an assay)    3 samples with low, middle and high level Renalase (RNLS) were tested 20 times on one plate, respectively.
 Inter-assay Precision (Precision between assays)    3 samples with low, middle and high level Renalase (RNLS) were tested on 3 different plates, 8 replicates in each plate.
 CV(%) =    SD/meanX100
 Intra-Assay    CV<10%
 Inter-Assay    CV<12%
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 Preparation and Storage    The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition.
To minimize extra influence on the performance, operation procedures and lab conditions, especially room temperature, air humidity, incubator temperature should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same operator from the beginning to the end.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of RNLS elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for RNLS purchase    MBS2020965 is a ready-to-use microwell, strip plate Double-antibody Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Renalase (RNLS) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 3.12-200ng/mL in biological research samples containing RNLS, with an estimated sensitivity of < 1.37ng/mL. The ELISA analytical biochemical technique of the MBS2020965 kit is based on RNLS antibody-RNLS antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect RNLS antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, RNLS. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Tissue homogenates, Cell lysates, Cell culture supernates and Other Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for RNLS elisa kit

   The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Renalase (RNLS). Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody specific to Renalase (RNLS). Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Renalase (RNLS), biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Renalase (RNLS) in the samples is then determined by comparing the O.D. of the samples to the standard curve.
 Product Categories/Family for RNLS elisa kit    Enzyme & Kinase
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 Typical Testing Data/Standard Curve (for reference only) of RNLS elisa kit    RNLS elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2020965. Click to request current manual
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NCBI/Uniprot data below describe general gene information for RNLS. It may not necessarily be applicable to this product.
 NCBI GI #    237649117
 NCBI GeneID    55328
 NCBI Accession #    NP_001026879.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001031709.2 [Other Products]
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 UniProt Primary Accession #    Q5VYX0 [Other Products]
 UniProt Secondary Accession #    Q9BS33; Q9NUP8 [Other Products]
 UniProt Related Accession #    Q5VYX0 [Other Products]
 Molecular Weight    34,949 Da
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 NCBI Official Full Name    renalase isoform 1
 NCBI Official Synonym Full Names    renalase, FAD-dependent amine oxidase
 NCBI Official Symbol    RNLS [Similar Products]
 NCBI Official Synonym Symbols   
C10orf59; RENALASE
[Similar Products]
 NCBI Protein Information    renalase
 UniProt Protein Name    Renalase
 UniProt Synonym Protein Names   
Monoamine oxidase-C; MAO-C; alpha-NAD(P)H oxidase/anomerase
 UniProt Gene Name    RNLS [Similar Products]
 UniProt Synonym Gene Names    C10orf59; MAO-C [Similar Products]
 UniProt Entry Name    RNLS_HUMAN
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 NCBI Summary for RNLS    Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney (Xu et al., 2005 [PubMed 15841207]).[supplied by OMIM, Mar 2008]
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 UniProt Comments for RNLS    RENALASE: Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. According to PubMed:17385068, is unlikely that renalase has physiologically relevant catecholamine-oxidizing activity. Belongs to the renalase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Secreted; EC; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10q23.31

Cellular Component: extracellular space

Molecular Function: oxidoreductase activity

Biological Process: heart contraction; regulation of systemic arterial blood pressure; epinephrine metabolic process; phosphate ion homeostasis; norepinephrine metabolic process; dopamine metabolic process
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 Research Articles on RNLS    1. study is the first to present reference values of urine renalase excretion in a healthy pediatric population
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with RNLS elisa kitDiseases associated with RNLS elisa kit
 Products by Pathway  Pathway Diagram
 Noradrenaline And Adrenaline Degradation Pathway antibodies  Noradrenaline And Adrenaline Degradation Pathway Diagram
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >2 publications with RNLS and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >2 publications with RNLS and Neoplasm Metastasis
 Hypertension Antibodies  >2 publications with RNLS and Hypertension
 Inflammation Antibodies  >2 publications with RNLS and Inflammation
 Kidney Diseases Antibodies  >1 publications with RNLS and Kidney Diseases
Organs/Tissues associated with RNLS elisa kit
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >1 publications with RNLS and Eye
 Kidney Antibodies  >1 publications with RNLS and Kidney
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