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SAA1 elisa kit :: Human SAA/SAA1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS178573
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
96-Strip-Wells  /  $390 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SAA/SAA1, ELISA Kit

★Popular Item★
 Also Known As   

Human SAA/SAA1 PicoKine ELISA Kit

 Product Synonym Names    SAA; saa 1; SAA1; Serum amyloid A 1 protein; Serum amyloid A protein precursor; P0DJI8; Serum amyloid A-1 protein; serum amyloid A1
 Product Gene Name   

SAA1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    104750
 3D Structure    ModBase 3D Structure for P0DJI8
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 Species Reactivity    Human
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 Specificity    Natural and recombinant Human SAA/SAA1
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 Samples    Cell culture supernates, serum and plasma(heparin, EDTA).
 Assay Type    Sandwich
 Detection Range    1.56ng/ml-100ng/ml
 Sensitivity    <150pg/ml
 Intra-assay Precision    Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision.
 Inter-assay Precision    Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision.
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 Preparation and Storage    Store at 4 degree C for 6 months, at -20 degree C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice).
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of SAA1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for SAA1 purchase    MBS178573 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the SAA/SAA1, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 1.56ng/ml-100ng/ml in biological research samples containing SAA1, with an estimated sensitivity of <150pg/ml. The ELISA analytical biochemical technique of the MBS178573 kit is based on SAA1 antibody-SAA1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SAA1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SAA1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Cell culture supernates, serum and plasma(heparin, EDTA). Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for SAA1 elisa kit

   Principle of the Assay: Human SAA/SAA1 ELISA Kit was based on standard sandwich enzyme-linked immunesorbent assay technology. A monoclonal antibody from mouse specific for SAA/SAA1 has been precoated onto 96-well plates. Standards(Expression system for standard: E.coli; Immunogen sequence: S20-Y122) and test samples are added to the wells, a biotinylated detection polyclonal antibody from goat specific for SAA/SAA1 is added subsequently and then followed by washing with PBS or TBS buffer. Avidin-Biotin-Peroxidase Complex was added and unbound conjugates were washed away with PBS or TBS buffer. HRP substrate TMB was used to visualize HRP enzymatic reaction. TMB was catalyzed by HRP to produce a blue color product that changed into yellow after adding acidic stop solution. The density of yellow is proportional to the Human SAA/SAA1 amount of sample captured in plate.

Background/Introduction: Serum amyloid A protein (SAA), also known as SAA1, is a protein that in humans is encoded by the SAA1 gene. This gene encodes a member of the serum amyloid A family of apolipoproteins. It is mapped to 11p15.1. SAA is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease.This protein may also be a potential biomarker for certain tumors.
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 Typical Testing Data/Standard Curve (for reference only) of SAA1 elisa kit    SAA1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS178573. Click to request current manual
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NCBI/Uniprot data below describe general gene information for SAA1. It may not necessarily be applicable to this product.
 NCBI GI #    40316912
 NCBI GeneID    6288
 NCBI Accession #    NP_000322.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000331.5 [Other Products]
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 UniProt Primary Accession #    P0DJI8 [Other Products]
 UniProt Secondary Accession #    P02735; P02736; P02737; Q16730; Q16834; Q16835; Q16879; Q3KRB3; Q6FG67; Q96QN0; Q9UCK9 [Other Products]
 UniProt Related Accession #    P0DJI8 [Other Products]
 Molecular Weight    13,532 Da
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 NCBI Official Full Name    serum amyloid A-1 protein preproprotein
 NCBI Official Synonym Full Names    serum amyloid A1
 NCBI Official Symbol    SAA1 [Similar Products]
 NCBI Official Synonym Symbols   
SAA; PIG4; SAA2; TP53I4
[Similar Products]
 NCBI Protein Information    serum amyloid A-1 protein
 UniProt Protein Name    Serum amyloid A-1 protein
 UniProt Synonym Protein Names   
Amyloid protein AAlternative name(s):Amyloid fibril protein AA
 Protein Family    Serum amyloid A-1 protein
 UniProt Gene Name    SAA1 [Similar Products]
 UniProt Synonym Gene Names    SAA [Similar Products]
 UniProt Entry Name    SAA1_HUMAN
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 NCBI Summary for SAA1    This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11. [provided by RefSeq, Feb 2016]
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 UniProt Comments for SAA1    SAA1: Major acute phase reactant. Apolipoprotein of the HDL complex. Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. Elevated serum SAA1 protein levels may be associated with lung cancer. Belongs to the SAA family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: cytoplasmic microtubule; extracellular region; extracellular space

Molecular Function: chemoattractant activity; G-protein-coupled receptor binding

Biological Process: activation of MAPK activity; cellular protein metabolic process; elevation of cytosolic calcium ion concentration; innate immune response; lymphocyte chemotaxis; macrophage chemotaxis; positive regulation of cell adhesion; positive regulation of cytokine secretion; receptor-mediated endocytosis
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 Research Articles on SAA1    1. incorporation of SAA into HDL preparations reduced antiinflammatory properties but not to the same extent as HDL from AgNO3-injected mice
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with SAA1 elisa kitDiseases associated with SAA1 elisa kit
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Advanced Glycosylation Endproduct Receptor Signaling Pathway antibodies  Advanced Glycosylation Endproduct Receptor Signaling Pathway Diagram
 Amyloid Fiber Formation Pathway antibodies  Amyloid Fiber Formation Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway antibodies  DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway Diagram
 Folate Metabolism Pathway antibodies  Folate Metabolism Pathway Diagram
 Formyl Peptide Receptors Bind Formyl Peptides And Many Other Ligands Pathway antibodies  Formyl Peptide Receptors Bind Formyl Peptides And Many Other Ligands Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >131 publications with SAA1 and Inflammation
 Necrosis Antibodies  >36 publications with SAA1 and Necrosis
 Cardiovascular Diseases Antibodies  >26 publications with SAA1 and Cardiovascular Diseases
 Liver Diseases Antibodies  >24 publications with SAA1 and Liver Diseases
 Disease Models, Animal Antibodies  >23 publications with SAA1 and Disease Models, Animal
 Kidney Diseases Antibodies  >23 publications with SAA1 and Kidney Diseases
 Atherosclerosis Antibodies  >21 publications with SAA1 and Atherosclerosis
 Liver Neoplasms Antibodies  >15 publications with SAA1 and Liver Neoplasms
 Lung Diseases Antibodies  >14 publications with SAA1 and Lung Diseases
 Carcinoma, Hepatocellular Antibodies  >12 publications with SAA1 and Carcinoma, Hepatocellular
Organs/Tissues associated with SAA1 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >92 publications with SAA1 and Liver
 Kidney Antibodies  >42 publications with SAA1 and Kidney
 Lung Antibodies  >18 publications with SAA1 and Lung
 Intestine Antibodies  >17 publications with SAA1 and Intestine
 Adipose Tissue Antibodies  >13 publications with SAA1 and Adipose Tissue
 Muscle Antibodies  >10 publications with SAA1 and Muscle
 Mammary Gland Antibodies  >7 publications with SAA1 and Mammary Gland
 Eye Antibodies  >4 publications with SAA1 and Eye
 Uterus Antibodies  >3 publications with SAA1 and Uterus
 Stomach Antibodies  >3 publications with SAA1 and Stomach
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