NP_001074493.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
80,636 Da
NCBI Official Full Name
histone-lysine N-methyltransferase SETDB2
NCBI Official Synonym Full Names
SET domain, bifurcated 2
NCBI Protein Information
histone-lysine N-methyltransferase SETDB2; Setdb2-Phf11-1-Phf11-2 fusion
UniProt Protein Name
Histone-lysine N-methyltransferase SETDB2
UniProt Synonym Protein Names
SET domain bifurcated 2
UniProt Synonym Gene Names
UniProt Entry Name
SETB2_MOUSE
UniProt Comments for SETDB2
SETDB2: Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis. Belongs to the histone-lysine methyltransferase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Methyltransferase, protein lysine; EC 2.1.1.43; Methyltransferase; Amino Acid Metabolism - lysine degradation
Cellular Component: chromosome; nucleus
Molecular Function: transferase activity; methyltransferase activity; DNA binding; zinc ion binding; metal ion binding; histone lysine N-methyltransferase activity (H3-K9 specific); histone-lysine N-methyltransferase activity
Biological Process: methylation; mitosis; cell division; multicellular organismal development; chromatin modification; cell cycle; chromosome segregation; histone H3-K9 methylation; peptidyl-lysine methylation
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Pathways associated with SETDB2 elisa kit
Diseases associated with SETDB2 elisa kit
Organs/Tissues associated with SETDB2 elisa kit
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