NP_001186193.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,977 Da
NCBI Official Full Name
serine/threonine-protein kinase Sgk2 isoform alpha
NCBI Official Synonym Full Names
serum/glucocorticoid regulated kinase 2
NCBI Protein Information
serine/threonine-protein kinase Sgk2
UniProt Protein Name
Serine/threonine-protein kinase Sgk2
UniProt Synonym Protein Names
Serum/glucocorticoid-regulated kinase 2
UniProt Entry Name
SGK2_HUMAN
NCBI Summary for SGK2
This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
UniProt Comments for SGK2
SGK2: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up- regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Highly expressed in liver, kidney and pancreas, and at lower levels in brain. Two specific sites, one in the kinase domain (Thr-253) and the other in the C-terminal regulatory region (Ser- 416), need to be phsphorylated for its full activation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Kinase, protein; Protein kinase, AGC; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); AGC group; SGK family
Chromosomal Location of Human Ortholog: 20q13.2
Cellular Component: cytosol; nucleus
Molecular Function: protein serine/threonine kinase activity; potassium channel regulator activity; sodium channel regulator activity; ATP binding
Biological Process: positive regulation of transporter activity; regulation of cell growth; response to oxidative stress; protein amino acid phosphorylation; transmembrane transport; regulation of cell proliferation
Research Articles on SGK2
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Products associated with SGK2 elisa kit
Pathways associated with SGK2 elisa kit
Diseases associated with SGK2 elisa kit
Organs/Tissues associated with SGK2 elisa kit
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