NP_112236.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,949 Da
NCBI Official Full Name
sharpin
NCBI Official Synonym Full Names
SHANK-associated RH domain interactor
NCBI Official Synonym Symbols
NCBI Protein Information
sharpin; hSIPL1; shank-interacting protein-like 1; shank-associated RH domain-interacting protein
UniProt Protein Name
Sharpin
UniProt Synonym Protein Names
Shank-associated RH domain-interacting protein; Shank-interacting protein-like 1; hSIPL1
UniProt Synonym Gene Names
UniProt Entry Name
SHRPN_HUMAN
UniProt Comments for SHARPIN
SHARPIN: Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Self-associates. Interacts with SHANK1, EYA1 and EYA2. Component of the LUBAC complex (linear ubiquitin chain assembly complex) which consists of SHARPIN, RBCK1 and RNF31. LUBAC has a MW of approximative 600 kDa suggesting a heteromultimeric assembly of its subunits. Associates with the TNF-R1 signaling complex (TNF-RSC) in a stimulation- dependent manner. Highly expressed in skeletal muscle and placenta and at lower levels in brain, heart, colon without mucosa, thymus, spleen, kidney, liver, small intestine, lung and peripheral blood leukocytes. Up-regulated in various tumor tissues such as kidney, liver, ovary and pancreas tumors. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component: nucleoplasm; dendrite; cytoplasm; postsynaptic density; cytosol; cell junction; nucleus
Molecular Function: identical protein binding; protein binding; zinc ion binding; protein complex binding; polyubiquitin binding
Biological Process: mitochondrion organization and biogenesis; positive regulation of I-kappaB kinase/NF-kappaB cascade; apoptotic nuclear changes; negative regulation of inflammatory response; keratinization; brain development; protein homooligomerization
Research Articles on SHARPIN
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Products associated with SHARPIN elisa kit
Diseases associated with SHARPIN elisa kit
Organs/Tissues associated with SHARPIN elisa kit
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