NP_001164108.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
120,881 Da
NCBI Official Full Name
SLIT-ROBO Rho GTPase-activating protein 2 isoform c
NCBI Official Synonym Full Names
SLIT-ROBO Rho GTPase activating protein 2
NCBI Official Synonym Symbols
FNBP2; SRGAP3; SRGAP2A; ARHGAP34 [Similar Products]
NCBI Protein Information
SLIT-ROBO Rho GTPase-activating protein 2; SLIT-ROBO GAP2; formin-binding protein 2; rho GTPase-activating protein 34
UniProt Protein Name
SLIT-ROBO Rho GTPase-activating protein 2
UniProt Synonym Protein Names
Formin-binding protein 2; Rho GTPase-activating protein 34
UniProt Synonym Gene Names
UniProt Entry Name
SRGP2_HUMAN
NCBI Summary for SRGAP2
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Jul 2014]
UniProt Comments for SRGAP2
SRGAP2: RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia. A chromosomal aberration disrupting SRGAP2 has been found in a patient with early infantile epileptic encephalopathy. Balanced translocation t(1;9)(q32;q13).
Protein type: GAPs, Rac/Rho; Motility/polarity/chemotaxis; Mitochondrial; GAPs
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component: postsynaptic membrane; lamellipodium; cytoplasm; postsynaptic density; plasma membrane; phagocytic vesicle; cell junction; cytosol; nucleus
Molecular Function: protein binding; protein homodimerization activity; Rac GTPase binding
Biological Process: cell proliferation; actin filament severing; axon guidance; regulation of small GTPase mediated signal transduction; extension of a leading process involved in cell locomotion in cerebral cortex radial glia guided migration; filopodium formation; small GTPase mediated signal transduction; neurite morphogenesis
Research Articles on SRGAP2
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Pathways associated with SRGAP2 elisa kit
Diseases associated with SRGAP2 elisa kit
Organs/Tissues associated with SRGAP2 elisa kit
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