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SOX3 elisa kit :: Human SOX3 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2504565
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
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 Product Name   

SOX3, ELISA Kit

★Popular Item★
 Also Known As   

Human SOX3 (Sex Determining Region Y Box Protein 3) ELISA Kit

 Product Gene Name   

SOX3 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    300123
 3D Structure    ModBase 3D Structure for P41225
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 Species Reactivity    Human
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 Specificity    This kit recognizes natural and recombinant Human SOX3. No significant cross-reactivity or interference between Human SOX3 and analogues was observed.
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 Samples    Serum, plasma and other biological fluids
 Assay Type    Quantitative Sandwich
 Detection Range    78.125-5000pg/mL
 Sensitivity    46.875pg/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of SOX3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for SOX3 purchase    MBS2504565 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the SOX3, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 78.125-5000pg/mL in biological research samples containing SOX3, with an estimated sensitivity of 46.875pg/mL. The ELISA analytical biochemical technique of the MBS2504565 kit is based on SOX3 antibody-SOX3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SOX3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SOX3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma and other biological fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for SOX3 elisa kit

   Intended Uses: This ELISA kit applies to the in vitro quantitative determination of Human SOX3 concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to SOX3. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for SOX3 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain SOX3, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of SOX3. You can calculate the concentration of SOX3 in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of SOX3 elisa kit    SOX3 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2504565. Click to request current manual
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NCBI/Uniprot data below describe general gene information for SOX3. It may not necessarily be applicable to this product.
 NCBI GI #    530020
 NCBI Accession #    CAA50465.1 [Other Products]
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 UniProt Primary Accession #    P41225 [Other Products]
 UniProt Secondary Accession #    P35714; Q5JWI3; Q9NP49 [Other Products]
 Molecular Weight    45,210 Da
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 NCBI Official Full Name    SOX3
 UniProt Protein Name    Transcription factor SOX-3
 Protein Family    Transcription factor
 UniProt Gene Name    SOX3 [Similar Products]
 UniProt Entry Name    SOX3_HUMAN
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 NCBI Summary for SOX3    This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene have been associated with X-linked mental retardation with growth hormone deficiency. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SOX3    SOX3: Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Defects in SOX3 are a cause of panhypopituitarism X- linked (PHPX). Affected individuals have absent infundibulum, anterior pituitary hypoplasia, and ectopic posterior pituitary. Defects in SOX3 are the cause of mental retardation X- linked with isolated growth hormone deficiency (MRXGH). Defects in SOX3 are the cause of 46,XX sex reversal type 3 (SRXX3). A condition in which male gonads develop in a genetic female (female to male sex reversal). Copy number variations (CNV) encompassing or in close proximity to SOX3 are responsible for XX male reversal. These variations include two duplications of approximately 123 kb and 85 kb, the former of which spans the entire SOX3 gene; a 343 kb deletion immediately upstream of SOX3 that is probably responsible of altered regulation (and not increased dosage) of SOX3; a large (approximately 6 Mb) duplication that encompasses SOX3 and at least 18 additional distally located genes. Its proximal breakpoint falls within the SOX3 regulatory region. This large rearrangement has been found in a patient with XX male reversal and a complex phenotype that also includes a scrotal hypoplasia, microcephaly, developmental delay, and growth retardation.

Protein type: Nuclear receptor co-regulator; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: Xq27.1

Cellular Component: nucleus

Molecular Function: DNA binding; transcription factor activity

Biological Process: sex determination; negative regulation of neuron differentiation; hypothalamus development; spermatid differentiation; organ morphogenesis; central nervous system development; sensory organ development; transcription, DNA-dependent; pituitary gland development; neuron development; negative regulation of transcription from RNA polymerase II promoter; Sertoli cell development

Disease: Panhypopituitarism, X-linked; Mental Retardation, X-linked, With Panhypopituitarism
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SOX3 elisa kitDiseases associated with SOX3 elisa kit
 Reference Product  PubMed Publications
 PAX6 elisa kit  >20 publications with SOX3 and PAX6
 DMRT1 elisa kit  >10 publications with SOX3 and DMRT1
 NANOG elisa kit  >6 publications with SOX3 and NANOG
 ATP11C elisa kit  >3 publications with SOX3 and ATP11C
 NEUROG2 elisa kit  >2 publications with SOX3 and NEUROG2
 MEIS1 elisa kit  >2 publications with SOX3 and MEIS1
 ASB11 elisa kit  >1 publications with SOX3 and ASB11
 NEUROG3 elisa kit  >1 publications with SOX3 and NEUROG3
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >42 publications with SOX3 and Nervous System Diseases
 Neurobehavioral Manifestations Antibodies  >11 publications with SOX3 and Neurobehavioral Manifestations
 Disease Models, Animal Antibodies  >7 publications with SOX3 and Disease Models, Animal
 Nervous System Malformations Antibodies  >5 publications with SOX3 and Nervous System Malformations
 Panhypopituitarism X-linked Antibodies  >4 publications with SOX3 and Panhypopituitarism X-linked
 Eye Diseases Antibodies  >3 publications with SOX3 and Eye Diseases
 Lung Diseases Antibodies  >3 publications with SOX3 and Lung Diseases
 Mental Retardation, X-Linked, With Panhypopituitarism Antibodies  >3 publications with SOX3 and Mental Retardation, X-Linked, With Panhypopituitarism
 Neoplasm Metastasis Antibodies  >2 publications with SOX3 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >2 publications with SOX3 and Breast Neoplasms
Organs/Tissues associated with SOX3 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >85 publications with SOX3 and Brain
 Embryonic Tissue Antibodies  >53 publications with SOX3 and Embryonic Tissue
 Testis Antibodies  >39 publications with SOX3 and Testis
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