NP_001005176.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
98,223 Da
NCBI Official Full Name
nuclear body protein SP140 isoform 2
NCBI Official Synonym Full Names
SP140 nuclear body protein
NCBI Protein Information
nuclear body protein SP140; speckled 140 kDa; nuclear autoantigen Sp-140; lymphoid-specific SP100 homolog; lymphoid-restricted homolog of Sp100
UniProt Protein Name
Nuclear body protein SP140
UniProt Synonym Protein Names
Lymphoid-restricted homolog of Sp100; LYSp100; Nuclear autoantigen Sp-140; Speckled 140 kDa
UniProt Synonym Gene Names
UniProt Entry Name
SP140_HUMAN
UniProt Comments for SP140
SP140: Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 2q37.1
Cellular Component: nucleoplasm; PML body; cytoplasm; nuclear envelope; nucleus
Molecular Function: protein binding; DNA binding; zinc ion binding; chromatin binding; transcription factor activity
Biological Process: chromatin remodeling; regulation of transcription, DNA-dependent; defense response
Research Articles on SP140
Precautions
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Disclaimer
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Diseases associated with SP140 elisa kit
Disease Name |
Pubmed Publications |
Leukemia, Lymphocytic, Chronic, B-Cell Antibodies |
>3 publications with SP140 and Leukemia, Lymphocytic, Chronic, B-Cell |
Cholangitis, Sclerosing Antibodies |
>1 publications with SP140 and Cholangitis, Sclerosing |
Genital Neoplasms, Female Antibodies |
>1 publications with SP140 and Genital Neoplasms, Female |
Laryngeal Neoplasms Antibodies |
>1 publications with SP140 and Laryngeal Neoplasms |
Organs/Tissues associated with SP140 elisa kit
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