NP_001007227.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,132 Da
NCBI Official Full Name
speckle-type POZ protein
NCBI Official Synonym Full Names
speckle-type POZ protein
NCBI Official Synonym Symbols
NCBI Protein Information
speckle-type POZ protein; HIB homolog 1; roadkill homolog 1
UniProt Protein Name
Speckle-type POZ protein
UniProt Synonym Protein Names
HIB homolog 1; Roadkill homolog 1
UniProt Entry Name
SPOP_HUMAN
NCBI Summary for SPOP
This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
UniProt Comments for SPOP
SPOP: Inhibits IPF1/PDX1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex. In complex with CUL3, involved in ubiquitination of BMI1, H2AFY and DAXX, and probably also in ubiquitination and proteasomal degradation of Gli2 or Gli3. Belongs to the Tdpoz family.
Chromosomal Location of Human Ortholog: 17q21.33
Cellular Component: nucleoplasm; nuclear speck; nucleus
Molecular Function: protein binding; ubiquitin protein ligase binding
Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination during ubiquitin-dependent protein catabolic process; glucose homeostasis
Research Articles on SPOP
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Products associated with SPOP elisa kit
Pathways associated with SPOP elisa kit
Diseases associated with SPOP elisa kit
Organs/Tissues associated with SPOP elisa kit
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